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10.1016/j.gene.2020.145368

http://scihub22266oqcxt.onion/10.1016/j.gene.2020.145368
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suck abstract from ncbi


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pmid33346100      Gene 2021 ; 771 (ä): 145368
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  • Recognition of plausible therapeutic agents to combat COVID-19: An omics data based combined approach #MMPMID33346100
  • Hossain MU; Bhattacharjee A; Emon MTH; Chowdhury ZM; Mosaib MG; Mourin M; Das KC; Keya CA; Salimullah M
  • Gene 2021[Mar]; 771 (ä): 145368 PMID33346100show ga
  • Coronavirus disease-2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has become an immense threat to global public health. In this study, we performed complete genome sequencing of a SARS-CoV-2 isolate. More than 67,000 genome sequences were further inspected from Global Initiative on Sharing All Influenza Data (GISAID). Using several in silico techniques, we proposed prospective therapeutics against this virus. Through meticulous analysis, several conserved and therapeutically suitable regions of SARS-CoV-2 such as RNA-dependent RNA polymerase (RdRp), Spike (S) and Membrane glycoprotein (M) coding genes were selected. Both S and M were chosen for the development of a chimeric vaccine that can generate memory B and T cells. siRNAs were also designed for S and M gene silencing. Moreover, six new drug candidates were suggested that might inhibit the activity of RdRp. Since SARS-CoV-2 and SARS-CoV-1 have 82.30% sequence identity, a Gene Expression Omnibus (GEO) dataset of Severe Acute Respiratory Syndrome (SARS) patients were analyzed. In this analysis, 13 immunoregulatory genes were found that can be used to develop type 1 interferon (IFN) based therapy. The proposed vaccine, siRNAs, drugs and IFN based analysis of this study will accelerate the development of new treatments.
  • |*COVID-19 Drug Treatment[MESH]
  • |Antiviral Agents/*pharmacology/therapeutic use[MESH]
  • |COVID-19/virology[MESH]
  • |Computational Biology/*methods[MESH]
  • |Computer Simulation[MESH]
  • |Conserved Sequence[MESH]
  • |Coronavirus M Proteins/genetics[MESH]
  • |Drug Design[MESH]
  • |Female[MESH]
  • |Gene Expression Profiling/*methods[MESH]
  • |Gene Expression Regulation, Viral/drug effects[MESH]
  • |Humans[MESH]
  • |Interferons/pharmacology[MESH]
  • |Middle Aged[MESH]
  • |Prospective Studies[MESH]
  • |RNA-Dependent RNA Polymerase/genetics[MESH]
  • |SARS-CoV-2/classification/*genetics[MESH]
  • |Sequence Analysis, RNA[MESH]
  • |Spike Glycoprotein, Coronavirus/genetics[MESH]


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