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10.1080/07853890.2020.1858234 http://scihub22266oqcxt.onion/10.1080/07853890.2020.1858234 33345622!7784832!33345622     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Med 2021 ; 53 (1): 197-207 Nephropedia Template TP {{tp|p=33345622|t=2021. Increased expression of hypoxia-induced factor 1alpha mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients |pdf=|usr=}}{{33345622}} gab.com Text Increased expression of hypoxia-induced factor 1alpha mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients JO: Ann Med http://www.kidney.de/pget.php?&tw=1&pmid=33345622 #FOAvip BACKGROUND: COVID-19 counts 46 million people infected and killed more than 1.2 million. Hypoxaemia is one of the main clinical manifestations, especially in severe cases. HIF1alpha is a master transcription factor involved in the cellular response to oxygen levels. The immunopathogenesis of this severe form of COVID-19 is poorly understood. METHODS: We performed scRNAseq from leukocytes from five critically ill COVID-19 patients and characterized the expression of hypoxia-inducible factor1alpha and its transcriptionally regulated genes. Also performed metanalysis from the publicly available RNAseq data from COVID-19 bronchoalveolar cells. RESULTS: Critically-ill COVID-19 patients show a shift towards an immature myeloid profile in peripheral blood cells, including band neutrophils, immature monocytes, metamyelocytes, monocyte-macrophages, monocytoid precursors, and promyelocytes-myelocytes, together with mature monocytes and segmented neutrophils. May be the result of a physiological response known as emergency myelopoiesis. These cellular subsets and bronchoalveolar cells express HIF1alpha and their transcriptional targets related to inflammation (CXCL8, CXCR1, CXCR2, and CXCR4); virus sensing, (TLR2 and TLR4); and metabolism (SLC2A3, PFKFB3, PGK1, GAPDH and SOD2). CONCLUSIONS: The up-regulation and participation of HIF1alpha in events such as inflammation, immunometabolism, and TLR make it a potential molecular marker for COVID-19 severity and, interestingly, could represent a potential target for molecular therapy. Key messages Critically ill COVID-19 patients show emergency myelopoiesis. HIF1alpha and its transcriptionally regulated genes are expressed in immature myeloid cells which could serve as molecular targets. HIF1alpha and its transcriptionally regulated genes is also expressed in lung cells from critically ill COVID-19 patients which may partially explain the hypoxia related events. Twit Text FOAVip Increased expression of hypoxia-induced factor 1alpha mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients ????Ann Med http://www.kidney.de/pget.php?&tw=1&pmid=33345622 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33345622 #FOAvip English Wikipedia <ref>{{Cite pmid|33345622}}</ref> Increased expression of hypoxia-induced factor 1alpha mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients #MMPMID33345622 Taniguchi-Ponciano K; Vadillo E; Mayani H; Gonzalez-Bonilla CR; Torres J; Majluf A; Flores-Padilla G; Wacher-Rodarte N; Galan JC; Ferat-Osorio E; Blanco-Favela F; Lopez-Macias C; Ferreira-Hermosillo A; Ramirez-Renteria C; Pena-Martinez E; Silva-Roman G; Vela-Patino S; Mata-Lozano C; Carvente-Garcia R; Basurto-Acevedo L; Saucedo R; Pina-Sanchez P; Chavez-Gonzalez A; Marrero-Rodriguez D; Mercado M Ann Med 2021[Dec]; 53 (1): 197-207 PMID33345622show ga BACKGROUND: COVID-19 counts 46 million people infected and killed more than 1.2 million. Hypoxaemia is one of the main clinical manifestations, especially in severe cases. HIF1alpha is a master transcription factor involved in the cellular response to oxygen levels. The immunopathogenesis of this severe form of COVID-19 is poorly understood. METHODS: We performed scRNAseq from leukocytes from five critically ill COVID-19 patients and characterized the expression of hypoxia-inducible factor1alpha and its transcriptionally regulated genes. Also performed metanalysis from the publicly available RNAseq data from COVID-19 bronchoalveolar cells. RESULTS: Critically-ill COVID-19 patients show a shift towards an immature myeloid profile in peripheral blood cells, including band neutrophils, immature monocytes, metamyelocytes, monocyte-macrophages, monocytoid precursors, and promyelocytes-myelocytes, together with mature monocytes and segmented neutrophils. May be the result of a physiological response known as emergency myelopoiesis. These cellular subsets and bronchoalveolar cells express HIF1alpha and their transcriptional targets related to inflammation (CXCL8, CXCR1, CXCR2, and CXCR4); virus sensing, (TLR2 and TLR4); and metabolism (SLC2A3, PFKFB3, PGK1, GAPDH and SOD2). CONCLUSIONS: The up-regulation and participation of HIF1alpha in events such as inflammation, immunometabolism, and TLR make it a potential molecular marker for COVID-19 severity and, interestingly, could represent a potential target for molecular therapy. Key messages Critically ill COVID-19 patients show emergency myelopoiesis. HIF1alpha and its transcriptionally regulated genes are expressed in immature myeloid cells which could serve as molecular targets. HIF1alpha and its transcriptionally regulated genes is also expressed in lung cells from critically ill COVID-19 patients which may partially explain the hypoxia related events. |*Critical Illness[MESH] |COVID-19/*genetics[MESH] |Female[MESH] |Humans[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*genetics[MESH] |Male[MESH] |Myeloid Cells/*metabolism[MESH] |RNA, Messenger/genetics[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |Sequence Analysis, RNA/*methods[MESH]Increased expression of hypoxia-induced factor 1alpha mRNA and its rel(epmc).pdf DeepDyve Pubget Overpricing