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10.3389/fgene.2020.584744 http://scihub22266oqcxt.onion/10.3389/fgene.2020.584744 33343631!7745755!33343631     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33343631&cmd=llinks): Failed to open stream: HTTP request failed! 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CRFK and Primary Macrophages Transcriptomes in Response to Feline Coronavirus Infection Differ Significantly |pdf=|usr=}}{{33343631}} gab.com Text CRFK and Primary Macrophages Transcriptomes in Response to Feline Coronavirus Infection Differ Significantly JO: Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=33343631 #FOAvip Coronaviruses are highly infectious and common in many species, including in humans, and agricultural and domestic animals. Host responses play an important role in viral entry, replication, assembly, and pathogenesis, although much is still to be understood, particularly host-virus interactions. Feline coronavirus is highly contagious, and ubiquitous in virtually all cat populations. Host-pathogen interactions have not been studied extensively due to the complex pathogenesis and development of clinical disease. Few studies have investigated cellular host responses to feline coronavirus infection, particularly at early time points. Transcriptome studies based on next-generation sequencing have the potential to elucidate the early responses of cells after viral infection and, consequently, give further insight into the pathogenesis of viruses. The current study aims to characterize and compare the viral- and immune-related differentially expressed genes in response to the coronavirus FIPV across different time points in a cell line which is permissive for productive replication versus primary cells implicated in pathogenesis. When comparing host responses in Crandell-Rees Feline Kidney (CRFK) cells to primary macrophages, many differences were observed with regards to expressed genes and their enrichments for both KEGG pathways and GO terms. CRFK cells which are permissive for productive replication of feline infectious peritonitis virus, showed induction of a large network of immunological and virally induced pathways. In contrast, Macrophages did not show similar host responses, with stronger pathway enrichment in downregulated transcripts. This study provides insights to better understand gene transcription in immune cells compared to epithelial cells discerning pathways relevant to pathogenesis in the early stages of infection. Twit Text FOAVip CRFK and Primary Macrophages Transcriptomes in Response to Feline Coronavirus Infection Differ Significantly ????Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=33343631 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33343631 #FOAvip English Wikipedia <ref>{{Cite pmid|33343631}}</ref> CRFK and Primary Macrophages Transcriptomes in Response to Feline Coronavirus Infection Differ Significantly #MMPMID33343631 Drechsler Y; Vasconcelos EJR; Griggs LM; Diniz PPPV Front Genet 2020[]; 11 (ä): 584744 PMID33343631show ga Coronaviruses are highly infectious and common in many species, including in humans, and agricultural and domestic animals. Host responses play an important role in viral entry, replication, assembly, and pathogenesis, although much is still to be understood, particularly host-virus interactions. Feline coronavirus is highly contagious, and ubiquitous in virtually all cat populations. Host-pathogen interactions have not been studied extensively due to the complex pathogenesis and development of clinical disease. Few studies have investigated cellular host responses to feline coronavirus infection, particularly at early time points. Transcriptome studies based on next-generation sequencing have the potential to elucidate the early responses of cells after viral infection and, consequently, give further insight into the pathogenesis of viruses. The current study aims to characterize and compare the viral- and immune-related differentially expressed genes in response to the coronavirus FIPV across different time points in a cell line which is permissive for productive replication versus primary cells implicated in pathogenesis. When comparing host responses in Crandell-Rees Feline Kidney (CRFK) cells to primary macrophages, many differences were observed with regards to expressed genes and their enrichments for both KEGG pathways and GO terms. CRFK cells which are permissive for productive replication of feline infectious peritonitis virus, showed induction of a large network of immunological and virally induced pathways. In contrast, Macrophages did not show similar host responses, with stronger pathway enrichment in downregulated transcripts. This study provides insights to better understand gene transcription in immune cells compared to epithelial cells discerning pathways relevant to pathogenesis in the early stages of infection. äCRFK and Primary Macrophages Transcriptomes in Response to Feline Coro(epmc).pdf DeepDyve Pubget Overpricing