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10.1093/bib/bbaa385 http://scihub22266oqcxt.onion/10.1093/bib/bbaa385 33341900!7799342!33341900     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brief+Bioinform 2021 ; 22 (2): 1338-1345 Nephropedia Template TP {{tp|p=33341900|t=2021. SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island loci |pdf=|usr=}}{{33341900}} gab.com Text SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island loci JO: Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=33341900 #FOAvip SARS-CoV-2 is an intensively investigated virus from the order Nidovirales (Coronaviridae family) that causes COVID-19 disease in humans. Through enormous scientific effort, thousands of viral strains have been sequenced to date, thereby creating a strong background for deep bioinformatics studies of the SARS-CoV-2 genome. In this study, we inspected high-frequency mutations of SARS-CoV-2 and carried out systematic analyses of their overlay with inverted repeat (IR) loci and CpG islands. The main conclusion of our study is that SARS-CoV-2 hot-spot mutations are significantly enriched within both IRs and CpG island loci. This points to their role in genomic instability and may predict further mutational drive of the SARS-CoV-2 genome. Moreover, CpG islands are strongly enriched upstream from viral ORFs and thus could play important roles in transcription and the viral life cycle. We hypothesize that hypermethylation of these loci will decrease the transcription of viral ORFs and could therefore limit the progression of the disease. Twit Text FOAVip SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island loci ????Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=33341900 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33341900 #FOAvip English Wikipedia <ref>{{Cite pmid|33341900}}</ref> SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island loci #MMPMID33341900 Goswami P; Bartas M; Lexa M; Bohalova N; Volna A; Cerven J; Cervenova V; Pecinka P; Spunda V; Fojta M; Brazda V Brief Bioinform 2021[Mar]; 22 (2): 1338-1345 PMID33341900show ga SARS-CoV-2 is an intensively investigated virus from the order Nidovirales (Coronaviridae family) that causes COVID-19 disease in humans. Through enormous scientific effort, thousands of viral strains have been sequenced to date, thereby creating a strong background for deep bioinformatics studies of the SARS-CoV-2 genome. In this study, we inspected high-frequency mutations of SARS-CoV-2 and carried out systematic analyses of their overlay with inverted repeat (IR) loci and CpG islands. The main conclusion of our study is that SARS-CoV-2 hot-spot mutations are significantly enriched within both IRs and CpG island loci. This points to their role in genomic instability and may predict further mutational drive of the SARS-CoV-2 genome. Moreover, CpG islands are strongly enriched upstream from viral ORFs and thus could play important roles in transcription and the viral life cycle. We hypothesize that hypermethylation of these loci will decrease the transcription of viral ORFs and could therefore limit the progression of the disease. |*CpG Islands[MESH] |*Mutation[MESH] |COVID-19/*virology[MESH] |DNA Methylation[MESH] |Genome, Viral[MESH] |Humans[MESH] |Protein Binding[MESH]SARS-CoV-2 hot-spot mutations are significantly enriched within invert(epmc).pdf DeepDyve Pubget Overpricing