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10.1016/j.neurad.2020.11.004

http://scihub22266oqcxt.onion/10.1016/j.neurad.2020.11.004
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suck abstract from ncbi


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pmid33340640      J+Neuroradiol 2021 ; 48 (3): 141-146
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  • Cerebral vasculitis of medium-sized vessels as a possible mechanism of brain damage in COVID-19 patients #MMPMID33340640
  • Lersy F; Anheim M; Willaume T; Chammas A; Brisset JC; Cotton F; Kremer S
  • J Neuroradiol 2021[May]; 48 (3): 141-146 PMID33340640show ga
  • BACKGROUND AND PURPOSE: Cerebral complications related to COVID-19 were recently reported, and the underlying mechanisms of brain damage remain uncertain, probably multifactorial. Among various hypotheses suggested, a possible vasculitis was issued but never confirmed. Herein, we aimed to describe brain MRIs focused on the intracranial vessel wall in a population of COVID-19 patients with neurologic manifestations. MATERIALS AND METHODS: Between March 1 and May 31, 2020, 69 consecutive COVID-19 patients with neurologic manifestations underwent a brain MRI allowing the study of the intracranial vessel wall at Strasbourg University hospitals and were retrospectively included. During the same period, 25 consecutive patients, without suspicion of SARS-CoV-2 infection, underwent a brain MRI urgently, with the same imaging protocols. A vasculitis seemed likely when imaging demonstrated vessel wall thickening with homogeneous and concentric enhancement. RESULTS: Among the 69 COVID-19 patients included, 11 (16%) presented arterial vessel wall thickening with homogeneous and concentric enhancement, compatible with cerebral vasculitis. These neuroimaging findings were not found among the 25 patients without SARS-CoV-2 infection, and the difference was statistically significant (p?=?0.03). Middle cerebral arteries, basilar artery, and posterior cerebral arteries were the most frequent vessels involved. For nine of them, imaging demonstrated ischemic or hemorrhagic complications. CONCLUSION: Cerebral vasculitis of medium-sized vessels seems to be one of the mechanisms at the origin of brain damage related to COVID-19.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Brain/*diagnostic imaging[MESH]
  • |COVID-19/*complications/diagnostic imaging[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Magnetic Resonance Angiography[MESH]
  • |Magnetic Resonance Imaging[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Neuroimaging[MESH]
  • |Retrospective Studies[MESH]
  • |Vasculitis, Central Nervous System/diagnostic imaging/*etiology[MESH]


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