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10.1016/j.immuni.2020.12.002 http://scihub22266oqcxt.onion/10.1016/j.immuni.2020.12.002 33338412!7834198!33338412     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2021 ; 54 (1): 44-52.e3 Nephropedia Template TP {{tp|p=33338412|t=2021. PD-1-Expressing SARS-CoV-2-Specific CD8(+) T Cells Are Not Exhausted, but Functional in Patients with COVID-19 |pdf=|usr=}}{{33338412}} gab.com Text PD-1-Expressing SARS-CoV-2-Specific CD8(+) T Cells Are Not Exhausted, but Functional in Patients with COVID-19 JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33338412 #FOAvip Memory T cell responses have been demonstrated in COVID-19 convalescents, but ex vivo phenotypes of SARS-CoV-2-specific T cells have been unclear. We detected SARS-CoV-2-specific CD8(+) T cells by MHC class I multimer staining and examined their phenotypes and functions in acute and convalescent COVID-19. Multimer(+) cells exhibited early differentiated effector-memory phenotypes in the early convalescent phase. The frequency of stem-like memory cells was increased among multimer(+) cells in the late convalescent phase. Cytokine secretion assays combined with MHC class I multimer staining revealed that the proportion of interferon-gamma (IFN-gamma)-producing cells was significantly lower among SARS-CoV-2-specific CD8(+) T cells than those specific to influenza A virus. Importantly, the proportion of IFN-gamma-producing cells was higher in PD-1(+) cells than PD-1(-) cells among multimer(+) cells, indicating that PD-1-expressing, SARS-CoV-2-specific CD8(+) T cells are not exhausted, but functional. Our current findings provide information for understanding of SARS-CoV-2-specific CD8(+) T cells elicited by infection or vaccination. Twit Text FOAVip PD-1-Expressing SARS-CoV-2-Specific CD8(+) T Cells Are Not Exhausted, but Functional in Patients with COVID-19 ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33338412 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33338412 #FOAvip English Wikipedia <ref>{{Cite pmid|33338412}}</ref> PD-1-Expressing SARS-CoV-2-Specific CD8(+) T Cells Are Not Exhausted, but Functional in Patients with COVID-19 #MMPMID33338412 Rha MS; Jeong HW; Ko JH; Choi SJ; Seo IH; Lee JS; Sa M; Kim AR; Joo EJ; Ahn JY; Kim JH; Song KH; Kim ES; Oh DH; Ahn MY; Choi HK; Jeon JH; Choi JP; Kim HB; Kim YK; Park SH; Choi WS; Choi JY; Peck KR; Shin EC Immunity 2021[Jan]; 54 (1): 44-52.e3 PMID33338412show ga Memory T cell responses have been demonstrated in COVID-19 convalescents, but ex vivo phenotypes of SARS-CoV-2-specific T cells have been unclear. We detected SARS-CoV-2-specific CD8(+) T cells by MHC class I multimer staining and examined their phenotypes and functions in acute and convalescent COVID-19. Multimer(+) cells exhibited early differentiated effector-memory phenotypes in the early convalescent phase. The frequency of stem-like memory cells was increased among multimer(+) cells in the late convalescent phase. Cytokine secretion assays combined with MHC class I multimer staining revealed that the proportion of interferon-gamma (IFN-gamma)-producing cells was significantly lower among SARS-CoV-2-specific CD8(+) T cells than those specific to influenza A virus. Importantly, the proportion of IFN-gamma-producing cells was higher in PD-1(+) cells than PD-1(-) cells among multimer(+) cells, indicating that PD-1-expressing, SARS-CoV-2-specific CD8(+) T cells are not exhausted, but functional. Our current findings provide information for understanding of SARS-CoV-2-specific CD8(+) T cells elicited by infection or vaccination. |Acute-Phase Reaction/immunology/virology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*immunology/pathology/virology[MESH] |Convalescence[MESH] |Epitopes, T-Lymphocyte[MESH] |Histocompatibility Antigens Class I/immunology[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Immunophenotyping[MESH] |Interferon-gamma/metabolism[MESH] |Lymphocyte Activation[MESH] |Programmed Cell Death 1 Receptor/*metabolism[MESH] |SARS-CoV-2/*immunology[MESH]PD-1-Expressing SARS-CoV-2-Specific CD8(+) T Cells Are Not Exhausted, (epmc).pdf DeepDyve Pubget Overpricing