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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Immunol 2021 ; 223 (ä): 108652 Nephropedia Template TP
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Influenza infection, SARS, MERS and COVID-19: Cytokine storm - The common denominator and the lessons to be learned #MMPMID33333256
Ryabkova VA; Churilov LP; Shoenfeld Y
Clin Immunol 2021[Feb]; 223 (ä): 108652 PMID33333256show ga
The outbreak of COVID-19 reminds us that the emerging and reemerging respiratory virus infections pose a continuing threat to human life. Cytokine storm syndromes of viral origin seem to have a common pathogenesis of the imbalanced immune response with the exaggerated inflammatory reaction combined with the reduction and functional exhaustion of T cells. Immunomodulatory therapy is gaining interest in COVID-19, but this strategy has received less attention in other respiratory viral infections than it deserved. In this review we suggest that based on the similarities of the immune dysfunction in the severe cases of different respiratory viral infections, some lessons from the immunomodulatory therapy of COVID-19 (particularly regarding the choice of an immunomodulatory drug, the selection of patients and optimal time window for this kind of therapy) could be applied for some cases of severe influenza infection and probably for some future outbreaks of novel severe respiratory viral infections.
|COVID-19/*immunology[MESH]
|Coronavirus Infections/*immunology[MESH]
|Cytokine Release Syndrome/*immunology[MESH]
|Cytokines/metabolism[MESH]
|Humans[MESH]
|Immunomodulation[MESH]
|Immunotherapy/*methods[MESH]
|Inflammation[MESH]
|Influenza, Human/*immunology[MESH]
|Middle East Respiratory Syndrome Coronavirus/*physiology[MESH]