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10.11606/s1518-8787.2020054003278

http://scihub22266oqcxt.onion/10.11606/s1518-8787.2020054003278
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suck abstract from ncbi


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pmid33331525      Rev+Saude+Publica 2020 ; 54 (ä): 131
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  • Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhao #MMPMID33331525
  • Silva AAMD; Lima-Neto LG; Azevedo CMPES; Costa LMMD; Braganca MLBM; Barros Filho AKD; Wittlin BB; Souza BF; Oliveira BLCA; Carvalho CA; Thomaz EBAF; Simoes-Neto EA; Leite Junior JF; Cosme LMSS; Campos MAG; Queiroz RCS; Costa SS; Carvalho VA; Simoes VMF; Alves MTSSBE; Santos AMD
  • Rev Saude Publica 2020[]; 54 (ä): 131 PMID33331525show ga
  • OBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhao, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys(R) Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas(R) e601 analyzer (Roche Diagnostics). RESULTS: In total, 3,156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40.4% (95%CI 35.6-45.3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 26.0% were asymptomatic. The infection fatality rate (IFR) was 0.14%, higher for men and older adults. The IFR based on excess deaths was 0.28%. The ratio of estimated infections to reported cases was 22.2. CONCLUSIONS: To the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey is one of the highest reported. The local herd immunity threshold may have been reached or might be reached soon.
  • |*Immunity, Herd[MESH]
  • |*Seroepidemiologic Studies[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |Brazil/epidemiology[MESH]
  • |COVID-19/*immunology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2[MESH]


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