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10.1016/j.ahr.2020.100001

http://scihub22266oqcxt.onion/10.1016/j.ahr.2020.100001
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33330852!7569417!33330852
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suck abstract from ncbi

pmid33330852      Aging+Health+Res 2021 ; 1 (1): 100001
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  • Unfolded protein response in the COVID-19 context #MMPMID33330852
  • Barabutis N
  • Aging Health Res 2021[Mar]; 1 (1): 100001 PMID33330852show ga
  • The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability. Dysregulation of this barrier contributes in the irreversible outcomes of the SARS-CoV-2 - inflicted acute respiratory distress syndrome (ARDS). Thus, it is highly probable that the targeted activation of those UPR components in charge of repairing the destructed lung endothelium of the COVID-19 patients, may deliver a promising therapeutic possibility for those subjected to the devastating outcomes of the ongoing pandemic.
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