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10.3389/fimmu.2020.606456

http://scihub22266oqcxt.onion/10.3389/fimmu.2020.606456
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suck abstract from ncbi


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pmid33329603      Front+Immunol 2020 ; 11 (ä): 606456
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  • Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling Pathways #MMPMID33329603
  • Mazewski C; Perez RE; Fish EN; Platanias LC
  • Front Immunol 2020[]; 11 (ä): 606456 PMID33329603show ga
  • For several decades there has been accumulating evidence implicating type I interferons (IFNs) as key elements of the immune response. Therapeutic approaches incorporating different recombinant type I IFN proteins have been successfully employed to treat a diverse group of diseases with significant and positive outcomes. The biological activities of type I IFNs are consequences of signaling events occurring in the cytoplasm and nucleus of cells. Biochemical events involving JAK/STAT proteins that control transcriptional activation of IFN-stimulated genes (ISGs) were the first to be identified and are referred to as "canonical" signaling. Subsequent identification of JAK/STAT-independent signaling pathways, critical for ISG transcription and/or mRNA translation, are denoted as "non-canonical" or "non-classical" pathways. In this review, we summarize these signaling cascades and discuss recent developments in the field, specifically as they relate to the biological and clinical implications of engagement of both canonical and non-canonical pathways.
  • |Animals[MESH]
  • |Humans[MESH]
  • |Interferon Type I/*immunology[MESH]
  • |Janus Kinases/immunology[MESH]
  • |Protein Biosynthesis/*immunology[MESH]
  • |STAT Transcription Factors/immunology[MESH]
  • |Signal Transduction/*immunology[MESH]


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