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10.1038/s41593-020-00771-8 http://scihub22266oqcxt.onion/10.1038/s41593-020-00771-8 33328624!8793077!33328624     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33328624&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Neurosci 2021 ; 24 (3): 368-378 Nephropedia Template TP {{tp|p=33328624|t=2021. The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice |pdf=|usr=}}{{33328624}} gab.com Text The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=33328624 #FOAvip It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its spike protein. We show that intravenously injected radioiodinated S1 (I-S1) readily crossed the blood-brain barrier in male mice, was taken up by brain regions and entered the parenchymal brain space. I-S1 was also taken up by the lung, spleen, kidney and liver. Intranasally administered I-S1 also entered the brain, although at levels roughly ten times lower than after intravenous administration. APOE genotype and sex did not affect whole-brain I-S1 uptake but had variable effects on uptake by the olfactory bulb, liver, spleen and kidney. I-S1 uptake in the hippocampus and olfactory bulb was reduced by lipopolysaccharide-induced inflammation. Mechanistic studies indicated that I-S1 crosses the blood-brain barrier by adsorptive transcytosis and that murine angiotensin-converting enzyme 2 is involved in brain and lung uptake, but not in kidney, liver or spleen uptake. Twit Text FOAVip The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=33328624 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33328624 #FOAvip English Wikipedia <ref>{{Cite pmid|33328624}}</ref> The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice #MMPMID33328624 Rhea EM; Logsdon AF; Hansen KM; Williams LM; Reed MJ; Baumann KK; Holden SJ; Raber J; Banks WA; Erickson MA Nat Neurosci 2021[Mar]; 24 (3): 368-378 PMID33328624show ga It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its spike protein. We show that intravenously injected radioiodinated S1 (I-S1) readily crossed the blood-brain barrier in male mice, was taken up by brain regions and entered the parenchymal brain space. I-S1 was also taken up by the lung, spleen, kidney and liver. Intranasally administered I-S1 also entered the brain, although at levels roughly ten times lower than after intravenous administration. APOE genotype and sex did not affect whole-brain I-S1 uptake but had variable effects on uptake by the olfactory bulb, liver, spleen and kidney. I-S1 uptake in the hippocampus and olfactory bulb was reduced by lipopolysaccharide-induced inflammation. Mechanistic studies indicated that I-S1 crosses the blood-brain barrier by adsorptive transcytosis and that murine angiotensin-converting enzyme 2 is involved in brain and lung uptake, but not in kidney, liver or spleen uptake. |Administration, Intranasal[MESH] |Administration, Intravenous[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Animals[MESH] |Apolipoproteins E/genetics[MESH] |Blood-Brain Barrier/*metabolism[MESH] |COVID-19[MESH] |Genotype[MESH] |Hippocampus/metabolism[MESH] |Humans[MESH] |Inflammation/chemically induced/metabolism[MESH] |Lipopolysaccharides/pharmacology[MESH] |Male[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Olfactory Bulb/metabolism[MESH] |Sex Characteristics[MESH] |Spike Glycoprotein, Coronavirus/administration & dosage/*pharmacokinetics[MESH] |Tissue Distribution[MESH]The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice (epmc).pdf DeepDyve Pubget Overpricing