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10.1038/s41380-020-00965-3 http://scihub22266oqcxt.onion/10.1038/s41380-020-00965-3 33328588!7738776!33328588     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33328588&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33328588.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Psychiatry 2021 ; 26 (4): 1044-1059 Nephropedia Template TP {{tp|p=33328588|t=2021. Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology |pdf=|usr=}}{{33328588}} gab.com Text Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology JO: Mol Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=33328588 #FOAvip Scientists and health professionals are exhaustively trying to contain the coronavirus disease 2019 (COVID-19) pandemic by elucidating viral invasion mechanisms, possible drugs to prevent viral infection/replication, and health cares to minimize individual exposure. Although neurological symptoms are being reported worldwide, neural acute and long-term consequences of SARS-CoV-2 are still unknown. COVID-19 complications are associated with exacerbated immunoinflammatory responses to SARS-CoV-2 invasion. In this scenario, pro-inflammatory factors are intensely released into the bloodstream, causing the so-called "cytokine storm". Both pro-inflammatory factors and viruses may cross the blood-brain barrier and enter the central nervous system, activating neuroinflammatory responses accompanied by hemorrhagic lesions and neuronal impairment, which are largely described processes in psychiatric disorders and neurodegenerative diseases. Therefore, SARS-CoV-2 infection could trigger and/or worse brain diseases. Moreover, patients with central nervous system disorders associated to neuroimmune activation (e.g. depression, Parkinson's and Alzheimer's disease) may present increased susceptibility to SARS-CoV-2 infection and/or achieve severe conditions. Elevated levels of extracellular ATP induced by SARS-CoV-2 infection may trigger hyperactivation of P2X7 receptors leading to NLRP3 inflammasome stimulation as a key mediator of neuroinvasion and consequent neuroinflammatory processes, as observed in psychiatric disorders and neurodegenerative diseases. In this context, P2X7 receptor antagonism could be a promising strategy to prevent or treat neurological complications in COVID-19 patients. Twit Text FOAVip Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology ????Mol Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=33328588 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33328588 #FOAvip English Wikipedia <ref>{{Cite pmid|33328588}}</ref> Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology #MMPMID33328588 Ribeiro DE; Oliveira-Giacomelli A; Glaser T; Arnaud-Sampaio VF; Andrejew R; Dieckmann L; Baranova J; Lameu C; Ratajczak MZ; Ulrich H Mol Psychiatry 2021[Apr]; 26 (4): 1044-1059 PMID33328588show ga Scientists and health professionals are exhaustively trying to contain the coronavirus disease 2019 (COVID-19) pandemic by elucidating viral invasion mechanisms, possible drugs to prevent viral infection/replication, and health cares to minimize individual exposure. Although neurological symptoms are being reported worldwide, neural acute and long-term consequences of SARS-CoV-2 are still unknown. COVID-19 complications are associated with exacerbated immunoinflammatory responses to SARS-CoV-2 invasion. In this scenario, pro-inflammatory factors are intensely released into the bloodstream, causing the so-called "cytokine storm". Both pro-inflammatory factors and viruses may cross the blood-brain barrier and enter the central nervous system, activating neuroinflammatory responses accompanied by hemorrhagic lesions and neuronal impairment, which are largely described processes in psychiatric disorders and neurodegenerative diseases. Therefore, SARS-CoV-2 infection could trigger and/or worse brain diseases. Moreover, patients with central nervous system disorders associated to neuroimmune activation (e.g. depression, Parkinson's and Alzheimer's disease) may present increased susceptibility to SARS-CoV-2 infection and/or achieve severe conditions. Elevated levels of extracellular ATP induced by SARS-CoV-2 infection may trigger hyperactivation of P2X7 receptors leading to NLRP3 inflammasome stimulation as a key mediator of neuroinvasion and consequent neuroinflammatory processes, as observed in psychiatric disorders and neurodegenerative diseases. In this context, P2X7 receptor antagonism could be a promising strategy to prevent or treat neurological complications in COVID-19 patients. |*Neuroimmunomodulation[MESH] |Brain Diseases/*complications/drug therapy/metabolism/*pathology[MESH] |COVID-19/*complications/immunology/metabolism/*pathology[MESH] |Humans[MESH] |Inflammasomes/immunology/metabolism[MESH] |Pandemics[MESH] |Receptors, Purinergic P2X7/*metabolism[MESH]Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathol(epmc).pdf DeepDyve Pubget Overpricing