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10.1016/j.jiac.2020.12.001

http://scihub22266oqcxt.onion/10.1016/j.jiac.2020.12.001
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33328135!7836222!33328135
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suck abstract from ncbi

pmid33328135      J+Infect+Chemother 2021 ; 27 (2): 387-389
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  • Prolonged viral shedding of SARS-CoV-2 in an immunocompromised patient #MMPMID33328135
  • Nakajima Y; Ogai A; Furukawa K; Arai R; Anan R; Nakano Y; Kurihara Y; Shimizu H; Misaki T; Okabe N
  • J Infect Chemother 2021[Feb]; 27 (2): 387-389 PMID33328135show ga
  • The duration of viral shedding of SARS-CoV-2 is usually less than 10 days. We experienced a COVID-19 case with prolonged viral shedding for 2 months. His cell mediated immunity has been depressed (CD4(+)T cell <100/mul) due to advanced malignant lymphoma and chemotherapy which had been completed 4 months prior to the onset of symptoms of COVID-19. We administered several treatments against COVID-19, however the results of Polymerase Chain Reaction (PCR) from nasopharyngeal specimens remained positive to SARS-CoV-2 for 2 months. Moreover, virus isolation assays performed on Day 59 also remained positive. He was finally discharged on Day 69 with two consecutive negative PCR results for SARS-CoV-2. Immunocompromised status may prolong viral shedding and it is therefore important for the clinician to take into account this when assessing such patients.
  • |*Immunocompromised Host[MESH]
  • |*Virus Shedding[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |COVID-19/complications/*immunology/therapy/virology[MESH]
  • |Humans[MESH]
  • |Lymphoma/*complications/virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx/virology[MESH]
  • |RNA, Viral/analysis[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction/methods[MESH]
  • |SARS-CoV-2/*isolation & purification[MESH]
  • |Time Factors[MESH]


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