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10.1016/j.immuni.2020.11.004 http://scihub22266oqcxt.onion/10.1016/j.immuni.2020.11.004 33326767!7664363!33326767     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2020 ; 53 (6): 1245-1257.e5 Nephropedia Template TP {{tp|p=33326767|t=2020. SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors |pdf=|usr=}}{{33326767}} gab.com Text SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33326767 #FOAvip Understanding the hallmarks of the immune response to SARS-CoV-2 is critical for fighting the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID-19 patients and healthy donors sampled both prior to and during the pandemic. Healthy donors examined during the pandemic exhibited increased numbers of SARS-CoV-2-specific T cells, but no humoral response. Their probable exposure to the virus resulted in either asymptomatic infection without antibody secretion or activation of preexisting immunity. In convalescent patients, we observed a public and diverse T cell response to SARS-CoV-2 epitopes, revealing T cell receptor (TCR) motifs with germline-encoded features. Bulk CD4(+) and CD8(+) T cell responses to the spike protein were mediated by groups of homologous TCRs, some of them shared across multiple donors. Overall, our results demonstrate that the T cell response to SARS-CoV-2, including the identified set of TCRs, can serve as a useful biomarker for surveying antiviral immunity. Twit Text FOAVip SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33326767 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33326767 #FOAvip English Wikipedia <ref>{{Cite pmid|33326767}}</ref> SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors #MMPMID33326767 Shomuradova AS; Vagida MS; Sheetikov SA; Zornikova KV; Kiryukhin D; Titov A; Peshkova IO; Khmelevskaya A; Dianov DV; Malasheva M; Shmelev A; Serdyuk Y; Bagaev DV; Pivnyuk A; Shcherbinin DS; Maleeva AV; Shakirova NT; Pilunov A; Malko DB; Khamaganova EG; Biderman B; Ivanov A; Shugay M; Efimov GA Immunity 2020[Dec]; 53 (6): 1245-1257.e5 PMID33326767show ga Understanding the hallmarks of the immune response to SARS-CoV-2 is critical for fighting the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID-19 patients and healthy donors sampled both prior to and during the pandemic. Healthy donors examined during the pandemic exhibited increased numbers of SARS-CoV-2-specific T cells, but no humoral response. Their probable exposure to the virus resulted in either asymptomatic infection without antibody secretion or activation of preexisting immunity. In convalescent patients, we observed a public and diverse T cell response to SARS-CoV-2 epitopes, revealing T cell receptor (TCR) motifs with germline-encoded features. Bulk CD4(+) and CD8(+) T cell responses to the spike protein were mediated by groups of homologous TCRs, some of them shared across multiple donors. Overall, our results demonstrate that the T cell response to SARS-CoV-2, including the identified set of TCRs, can serve as a useful biomarker for surveying antiviral immunity. |Adolescent[MESH] |Adult[MESH] |Antibodies, Viral/metabolism[MESH] |Asymptomatic Infections[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*immunology[MESH] |Cells, Cultured[MESH] |Convalescence[MESH] |Epitopes, T-Lymphocyte/immunology/*metabolism[MESH] |Female[MESH] |Humans[MESH] |Immunity[MESH] |Immunologic Memory[MESH] |Lymphocyte Activation[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Receptors, Antigen, T-Cell/metabolism[MESH] |SARS-CoV-2/*physiology[MESH] |Spike Glycoprotein, Coronavirus/immunology/*metabolism[MESH]SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire (epmc).pdf DeepDyve Pubget Overpricing