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10.3390/v12121423 http://scihub22266oqcxt.onion/10.3390/v12121423 33322045!7762994!33322045     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2020 ; 12 (12): ä Nephropedia Template TP {{tp|p=33322045|t=2020. Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses |pdf=|usr=}}{{33322045}} gab.com Text Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33322045 #FOAvip Recent RNA virus outbreaks such as Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Ebola virus (EBOV) have caused worldwide health emergencies highlighting the urgent need for new antiviral strategies. Targeting host cell pathways supporting viral replication is an attractive approach for development of antiviral compounds, especially with new, unexplored viruses where knowledge of virus biology is limited. Here, we present a strategy to identify host-targeted small molecule inhibitors using an image-based phenotypic antiviral screening assay followed by extensive target identification efforts revealing altered cellular pathways upon antiviral compound treatment. The newly discovered antiviral compounds showed broad-range antiviral activity against pathogenic RNA viruses such as SARS-CoV-2, EBOV and Crimean-Congo hemorrhagic fever virus (CCHFV). Target identification of the antiviral compounds by thermal protein profiling revealed major effects on proteostasis pathways and disturbance in interactions between cellular HSP70 complex and viral proteins, illustrating the supportive role of HSP70 on many RNA viruses across virus families. Collectively, this strategy identifies new small molecule inhibitors with broad antiviral activity against pathogenic RNA viruses, but also uncovers novel virus biology urgently needed for design of new antiviral therapies. Twit Text FOAVip Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33322045 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33322045 #FOAvip English Wikipedia <ref>{{Cite pmid|33322045}}</ref> Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses #MMPMID33322045 Tampere M; Pettke A; Salata C; Wallner O; Koolmeister T; Cazares-Korner A; Visnes T; Hesselman MC; Kunold E; Wiita E; Kalderen C; Lightowler M; Jemth AS; Lehtio J; Rosenquist A; Warpman-Berglund U; Helleday T; Mirazimi A; Jafari R; Puumalainen MR Viruses 2020[Dec]; 12 (12): ä PMID33322045show ga Recent RNA virus outbreaks such as Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Ebola virus (EBOV) have caused worldwide health emergencies highlighting the urgent need for new antiviral strategies. Targeting host cell pathways supporting viral replication is an attractive approach for development of antiviral compounds, especially with new, unexplored viruses where knowledge of virus biology is limited. Here, we present a strategy to identify host-targeted small molecule inhibitors using an image-based phenotypic antiviral screening assay followed by extensive target identification efforts revealing altered cellular pathways upon antiviral compound treatment. The newly discovered antiviral compounds showed broad-range antiviral activity against pathogenic RNA viruses such as SARS-CoV-2, EBOV and Crimean-Congo hemorrhagic fever virus (CCHFV). Target identification of the antiviral compounds by thermal protein profiling revealed major effects on proteostasis pathways and disturbance in interactions between cellular HSP70 complex and viral proteins, illustrating the supportive role of HSP70 on many RNA viruses across virus families. Collectively, this strategy identifies new small molecule inhibitors with broad antiviral activity against pathogenic RNA viruses, but also uncovers novel virus biology urgently needed for design of new antiviral therapies. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Cell Line[MESH] |Ebolavirus/drug effects/physiology[MESH] |HSP70 Heat-Shock Proteins/metabolism[MESH] |Hemorrhagic Fever Virus, Crimean-Congo/drug effects/physiology[MESH] |Host-Pathogen Interactions/*drug effects[MESH] |Humans[MESH] |Protein Binding/drug effects[MESH] |Protein Stability[MESH] |Proteome/drug effects[MESH] |Proteostasis/drug effects[MESH] |RNA Virus Infections/metabolism/virology[MESH] |RNA Viruses/*drug effects/physiology[MESH] |SARS-CoV-2/drug effects/physiology[MESH] |Small Molecule Libraries/pharmacology[MESH] |Viral Proteins/metabolism[MESH]Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essen(epmc).pdf DeepDyve Pubget Overpricing