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10.1016/j.isci.2020.101896 http://scihub22266oqcxt.onion/10.1016/j.isci.2020.101896 33319166!7721347!33319166     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2021 ; 24 (1): 101896 Nephropedia Template TP {{tp|p=33319166|t=2021. Transcriptional response modules characterize IL-1beta and IL-6 activity in COVID-19 |pdf=|usr=}}{{33319166}} gab.com Text Transcriptional response modules characterize IL-1beta and IL-6 activity in COVID-19 JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=33319166 #FOAvip Dysregulated IL-1beta and IL-6 responses have been implicated in the pathogenesis of severe Coronavirus Disease 2019 (COVID-19). Innovative approaches for evaluating the biological activity of these cytokines in vivo are urgently needed to complement clinical trials of therapeutic targeting of IL-1beta and IL-6 in COVID-19. We show that the expression of IL-1beta or IL-6 inducible transcriptional signatures (modules) reflects the bioactivity of these cytokines in immunopathology modelled by juvenile idiopathic arthritis (JIA) and rheumatoid arthritis. In COVID-19, elevated expression of IL-1beta and IL-6 response modules, but not the cytokine transcripts themselves, is a feature of infection in the nasopharynx and blood but is not associated with severity of COVID-19 disease, length of stay, or mortality. We propose that IL-1beta and IL-6 transcriptional response modules provide a dynamic readout of functional cytokine activity in vivo, aiding quantification of the biological effects of immunomodulatory therapies in COVID-19. Twit Text FOAVip Transcriptional response modules characterize IL-1beta and IL-6 activity in COVID-19 ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=33319166 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33319166 #FOAvip English Wikipedia <ref>{{Cite pmid|33319166}}</ref> Transcriptional response modules characterize IL-1beta and IL-6 activity in COVID-19 #MMPMID33319166 Bell LCK; Meydan C; Kim J; Foox J; Butler D; Mason CE; Shapira SD; Noursadeghi M; Pollara G iScience 2021[Jan]; 24 (1): 101896 PMID33319166show ga Dysregulated IL-1beta and IL-6 responses have been implicated in the pathogenesis of severe Coronavirus Disease 2019 (COVID-19). Innovative approaches for evaluating the biological activity of these cytokines in vivo are urgently needed to complement clinical trials of therapeutic targeting of IL-1beta and IL-6 in COVID-19. We show that the expression of IL-1beta or IL-6 inducible transcriptional signatures (modules) reflects the bioactivity of these cytokines in immunopathology modelled by juvenile idiopathic arthritis (JIA) and rheumatoid arthritis. In COVID-19, elevated expression of IL-1beta and IL-6 response modules, but not the cytokine transcripts themselves, is a feature of infection in the nasopharynx and blood but is not associated with severity of COVID-19 disease, length of stay, or mortality. We propose that IL-1beta and IL-6 transcriptional response modules provide a dynamic readout of functional cytokine activity in vivo, aiding quantification of the biological effects of immunomodulatory therapies in COVID-19. äTranscriptional response modules characterize IL-1beta and IL-6 activi(epmc).pdf DeepDyve Pubget Overpricing