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10.1038/s41598-020-78818-w http://scihub22266oqcxt.onion/10.1038/s41598-020-78818-w 33318519!7736291!33318519     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33318519&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2020 ; 10 (1): 21863 Nephropedia Template TP {{tp|p=33318519|t=2020. Gene expression network analysis provides potential targets against SARS-CoV-2 |pdf=|usr=}}{{33318519}} gab.com Text Gene expression network analysis provides potential targets against SARS-CoV-2 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33318519 #FOAvip Cell entry of SARS-CoV-2, the novel coronavirus causing COVID-19, is facilitated by host cell angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). We aimed to identify and characterize genes that are co-expressed with ACE2 and TMPRSS2, and to further explore their biological functions and potential as druggable targets. Using the gene expression profiles of 1,038 lung tissue samples, we performed a weighted gene correlation network analysis (WGCNA) to identify modules of co-expressed genes. We explored the biology of co-expressed genes using bioinformatics databases, and identified known drug-gene interactions. ACE2 was in a module of 681 co-expressed genes; 10 genes with moderate-high correlation with ACE2 (r > 0.3, FDR < 0.05) had known interactions with existing drug compounds. TMPRSS2 was in a module of 1,086 co-expressed genes; 31 of these genes were enriched in the gene ontology biologic process 'receptor-mediated endocytosis', and 52 TMPRSS2-correlated genes had known interactions with drug compounds. Dozens of genes are co-expressed with ACE2 and TMPRSS2, many of which have plausible links to COVID-19 pathophysiology. Many of the co-expressed genes are potentially targetable with existing drugs, which may accelerate the development of COVID-19 therapeutics. Twit Text FOAVip Gene expression network analysis provides potential targets against SARS-CoV-2 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33318519 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33318519 #FOAvip English Wikipedia <ref>{{Cite pmid|33318519}}</ref> Gene expression network analysis provides potential targets against SARS-CoV-2 #MMPMID33318519 Hernandez Cordero AI; Li X; Yang CX; Milne S; Bosse Y; Joubert P; Timens W; van den Berge M; Nickle D; Hao K; Sin DD Sci Rep 2020[Dec]; 10 (1): 21863 PMID33318519show ga Cell entry of SARS-CoV-2, the novel coronavirus causing COVID-19, is facilitated by host cell angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). We aimed to identify and characterize genes that are co-expressed with ACE2 and TMPRSS2, and to further explore their biological functions and potential as druggable targets. Using the gene expression profiles of 1,038 lung tissue samples, we performed a weighted gene correlation network analysis (WGCNA) to identify modules of co-expressed genes. We explored the biology of co-expressed genes using bioinformatics databases, and identified known drug-gene interactions. ACE2 was in a module of 681 co-expressed genes; 10 genes with moderate-high correlation with ACE2 (r > 0.3, FDR < 0.05) had known interactions with existing drug compounds. TMPRSS2 was in a module of 1,086 co-expressed genes; 31 of these genes were enriched in the gene ontology biologic process 'receptor-mediated endocytosis', and 52 TMPRSS2-correlated genes had known interactions with drug compounds. Dozens of genes are co-expressed with ACE2 and TMPRSS2, many of which have plausible links to COVID-19 pathophysiology. Many of the co-expressed genes are potentially targetable with existing drugs, which may accelerate the development of COVID-19 therapeutics. |*Transcriptome[MESH] |Adult[MESH] |Aged[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |COVID-19/*metabolism[MESH] |Cohort Studies[MESH] |Databases, Chemical[MESH] |Female[MESH] |Humans[MESH] |Lung/*metabolism/pathology[MESH] |Male[MESH] |Middle Aged[MESH] |Receptors, Coronavirus/*metabolism[MESH]Gene expression network analysis provides potential targets against SA(epmc).pdf DeepDyve Pubget Overpricing