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CRISPR-Based Approaches for Efficient and Accurate Detection of SARS-CoV-2 #MMPMID33316059
Zhang W; Liu K; Zhang P; Cheng W; Li L; Zhang F; Yu Z; Li L; Zhang X
Lab Med 2021[Mar]; 52 (2): 116-121 PMID33316059show ga
An outbreak of COVID-19, caused by infection with SARS-CoV-2 in Wuhan, China in December 2019, spread throughout the country and around the world, quickly. The primary detection technique for SARS-CoV-2, the reverse-transcription polymerase chain reaction (RT-PCR)-based approach, requires expensive reagents and equipment and skilled personnel. In addition, for SARS-CoV-2 detection, specimens are usually shipped to a designated laboratory for testing, which may extend the diagnosis and treatment time of patients with COVID-19. The latest research shows that clustered regularly interspaced short palindromic repeats (CRISPR)-based approaches can quickly provide visual, rapid, ultrasensitive, and specific detection of SARS-CoV-2 at isothermal conditions. Therefore, CRISPR-based approaches are expected to be developed as attractive alternatives to conventional RT-PCR methods for the efficient and accurate detection of SARS-CoV-2. Recent advances in the field of CRISPR-based biosensing technologies for SARS-CoV-2 detection and insights into their potential use in many applications are reviewed in this article.
|*COVID-19 Nucleic Acid Testing[MESH]
|*Clustered Regularly Interspaced Short Palindromic Repeats[MESH]