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10.3389/fimmu.2020.603507 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.603507 33312178!7708330!33312178     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 603507 Nephropedia Template TP {{tp|p=33312178|t=2020. MAFB and MAF Transcription Factors as Macrophage Checkpoints for COVID-19 Severity |pdf=|usr=}}{{33312178}} gab.com Text MAFB and MAF Transcription Factors as Macrophage Checkpoints for COVID-19 Severity JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33312178 #FOAvip Defective IFN production and exacerbated inflammatory and pro-fibrotic responses are hallmarks of SARS-CoV-2 infection in severe COVID-19. Based on these hallmarks, and considering the pivotal role of macrophages in COVID-19 pathogenesis, we hypothesize that the transcription factors MAFB and MAF critically contribute to COVID-19 progression by shaping the response of macrophages to SARS-CoV-2. Our proposal stems from the recent identification of pathogenic lung macrophage subsets in severe COVID-19, and takes into consideration the previously reported ability of MAFB to dampen IFN type I production, as well as the critical role of MAFB and MAF in the acquisition and maintenance of the transcriptional signature of M-CSF-conditioned human macrophages. Solid evidences are presented that link overexpression of MAFB and silencing of MAF expression with clinical and biological features of severe COVID-19. As a whole, we propose that a high MAFB/MAF expression ratio in lung macrophages could serve as an accurate diagnostic tool for COVID-19 progression. Indeed, reversing the macrophage MAFB/MAF expression ratio might impair the exacerbated inflammatory and profibrotic responses, and restore the defective IFN type I production, thus becoming a potential strategy to limit severity of COVID-19. Twit Text FOAVip MAFB and MAF Transcription Factors as Macrophage Checkpoints for COVID-19 Severity ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33312178 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33312178 #FOAvip English Wikipedia <ref>{{Cite pmid|33312178}}</ref> MAFB and MAF Transcription Factors as Macrophage Checkpoints for COVID-19 Severity #MMPMID33312178 Vega MA; Simon-Fuentes M; Gonzalez de la Aleja A; Nieto C; Colmenares M; Herrero C; Dominguez-Soto A; Corbi AL Front Immunol 2020[]; 11 (ä): 603507 PMID33312178show ga Defective IFN production and exacerbated inflammatory and pro-fibrotic responses are hallmarks of SARS-CoV-2 infection in severe COVID-19. Based on these hallmarks, and considering the pivotal role of macrophages in COVID-19 pathogenesis, we hypothesize that the transcription factors MAFB and MAF critically contribute to COVID-19 progression by shaping the response of macrophages to SARS-CoV-2. Our proposal stems from the recent identification of pathogenic lung macrophage subsets in severe COVID-19, and takes into consideration the previously reported ability of MAFB to dampen IFN type I production, as well as the critical role of MAFB and MAF in the acquisition and maintenance of the transcriptional signature of M-CSF-conditioned human macrophages. Solid evidences are presented that link overexpression of MAFB and silencing of MAF expression with clinical and biological features of severe COVID-19. As a whole, we propose that a high MAFB/MAF expression ratio in lung macrophages could serve as an accurate diagnostic tool for COVID-19 progression. Indeed, reversing the macrophage MAFB/MAF expression ratio might impair the exacerbated inflammatory and profibrotic responses, and restore the defective IFN type I production, thus becoming a potential strategy to limit severity of COVID-19. |COVID-19/genetics/*immunology/virology[MESH] |Gene Expression Profiling/methods[MESH] |Gene Expression Regulation/genetics/immunology[MESH] |Host-Pathogen Interactions/genetics/immunology[MESH] |Humans[MESH] |Macrophages/*immunology/metabolism[MESH] |Maf Transcription Factors/genetics/*immunology/metabolism[MESH] |MafB Transcription Factor/genetics/*immunology/metabolism[MESH] |SARS-CoV-2/*immunology/physiology[MESH]MAFB and MAF Transcription Factors as Macrophage Checkpoints for COVID(epmc).pdf DeepDyve Pubget Overpricing