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10.12659/AJCR.928422

http://scihub22266oqcxt.onion/10.12659/AJCR.928422
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33311431!7751801!33311431
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suck abstract from ncbi


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pmid33311431      Am+J+Case+Rep 2020 ; 21 (ä): e928422
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  • Three Cases of COVID-19 Pneumonia That Responded to Icosapent Ethyl Supportive Treatment #MMPMID33311431
  • Suh W; Urits I; Viswanath O; Kaye AD; Patel H; Hall W; Eskander JP
  • Am J Case Rep 2020[Dec]; 21 (ä): e928422 PMID33311431show ga
  • BACKGROUND Icosapent ethyl, a form of eicosapentaenoic acid with anti-inflammatory activity, has been approved as an adjunctive treatment with statins in patients with hypertriglyceridemia. Icosapent ethyl is currently undergoing clinical trials to determine its anti-inflammatory effects in patients with coronavirus disease 2019 (COVID-19). This report describes 3 intensive care unit (ICU) patients with moderate to severe COVID-19 pneumonia treated with icosapent ethyl as part of their supportive care who had favorable outcomes. CASE REPORT Case 1 was a 75-year-old man with a past medical history of hyperlipidemia, hypertension, type 2 diabetes mellitus, obesity, and benign prostatic hyperplasia. Case 2 was a 23-year old man with a past medical history of type 2 diabetes mellitus and obesity. Case 3 was a 24-year old man with a history of autism. All cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were confirmed from a nasopharyngeal swab using the Becton Dickinson nasopharyngeal reverse-transcription polymerase chain reaction. All patients in these cases were treated with a course of 2 g of icosapent ethyl twice a day by nasogastric tube. CONCLUSIONS This report of 3 cases describes the use of icosapent ethyl as a component of supportive treatments in ICU patients with moderate to severe COVID-19 pneumonia. However, as of yet there are no evidence-based treatments for SARS-CoV-2 infection from controlled clinical trials. The outcomes of ongoing clinical trials are awaited to determine whether icosapent ethyl has anti-inflammatory effects in patients with SARS-CoV-2 infection and which patients might benefit from the use of this adjunctive treatment.
  • |*COVID-19 Drug Treatment[MESH]
  • |Aged[MESH]
  • |Eicosapentaenoic Acid/*analogs & derivatives/therapeutic use[MESH]
  • |Humans[MESH]
  • |Male[MESH]


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