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10.1016/j.intimp.2020.107271

http://scihub22266oqcxt.onion/10.1016/j.intimp.2020.107271
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33310664!7724312!33310664
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suck abstract from ncbi


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pmid33310664      Int+Immunopharmacol 2021 ; 90 (ä): 107271
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  • Persistence of SARS-CoV-2-specific antibodies in COVID-19 patients #MMPMID33310664
  • Wang Y; Li J; Li H; Lei P; Shen G; Yang C
  • Int Immunopharmacol 2021[Jan]; 90 (ä): 107271 PMID33310664show ga
  • To better understand humoral immunity following SARS-CoV-2 infection, 114 hospitalised COVID-19 patients with antibody monitored over 8 weeks from symptom onset were retrospectively investigated. A total of 445 serum samples were assessed via chemiluminescence immunoassay. Positive rate of virus-specific IgM reached up to over 80% from the second week to the eighth week after symptom onset, then declined quickly to below 30% in the twelfth week. Concentrations of IgG remained high for at least 3 months before subsequently declining. As compared with the non-severe group, serum IgM level from week 3 to week 8 was significantly higher among the patients with severe clinical symptoms (P = 0.012) but not IgG (P = 0.053). Serum IgM level from week 3 to week 8 was correlated with positive virus RNA test (r = 0.201, P = 0.044), albumin level (r = -0.295, P = 0.003), lactic dehydrogenase (LDH) level (r = 0.292, P = 0.003), alkaline phosphatase (ALP) level (r = 0.254, P = 0.010), C-reactive protein (CRP) level (r = 0.281, P = 0.004) during the same course, while serum IgG level was correlated with age (r = 0.207, P = 0.038). This presented results provide insight into duration of SARS-CoV-2 antibodies and interaction between the virus and host systems.
  • |*SARS-CoV-2[MESH]
  • |Aged[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19/*blood/immunology/virology[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/*blood[MESH]
  • |Immunoglobulin M/*blood[MESH]
  • |L-Lactate Dehydrogenase/blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |RNA, Viral/analysis[MESH]
  • |Retrospective Studies[MESH]
  • |Serum Albumin/analysis[MESH]


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