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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Diabetes+Res+Clin+Pract 2021 ; 173 (ä): 108619 Nephropedia Template TP
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Association of metformin with mortality or ARDS in patients with COVID-19 and type 2 diabetes: A retrospective cohort study #MMPMID33310173
Jiang N; Chen Z; Liu L; Yin X; Yang H; Tan X; Wang J; Li H; Tian M; Lu Z; Xiong N; Gong Y
Diabetes Res Clin Pract 2021[Mar]; 173 (ä): 108619 PMID33310173show ga
AIMS: To determine the association between metformin use and mortality and ARDS incidence in patients with COVID-19 and type 2 diabetes. METHODS: This study was a multi-center retrospective analysis of COVID-19 patients with type 2 diabetes and admitted to four hospitals in Hubei province, China from December 31st, 2019 to March 31st, 2020. Patients were divided into two groups according to their exposure to metformin during hospitalization. The outcomes of interest were 30-day all-cause mortality and incidence of ARDS. We used mixed-effect Cox model and random effect logistic regression to evaluate the associations of metformin use with outcomes, adjusted for baseline characteristics. RESULTS: Of 328 patients with COVID-19 and type 2 diabetes included in the study cohort, 30.5% (100/328) were in the metformin group. In the mixed-effected model, metformin use was associated with the lower incidence of ARDS. There was no significant association between metformin use and 30-day all-cause mortality. Propensity score-matched analysis confirmed the results. In the subgroup analysis, metformin use was associated with the lower incidence of ARDS in females. CONCLUSIONS: Metformin may have potential benefits in reducing the incidence of ARDS in patients with COVID-19 and type 2 diabetes. However, this benefit differs significantly by gender.
|Aged[MESH]
|COVID-19/complications/*mortality[MESH]
|China/epidemiology[MESH]
|Cohort Studies[MESH]
|Diabetes Mellitus, Type 2/complications/*drug therapy/*mortality[MESH]