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10.1016/j.pharmthera.2020.107794 http://scihub22266oqcxt.onion/10.1016/j.pharmthera.2020.107794 33310156!8027699!33310156     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33310156&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Pharmacol+Ther 2021 ; 222 (?): 107794 Nephropedia Template TP {{tp|p=33310156|t=2021. The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response |pdf=|usr=}}{{33310156}} gab.com Text The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response JO: Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=33310156 #FOAvip Obesity and the metabolic syndrome (MetS), which have reached pandemic proportions significantly increase the risk for type 2 diabetes, cardiovascular disease, and other serious conditions. Recent data with COVID-19 patients indicate that obesity also is a significant risk factor for this novel viral disease and poor outcome of associated critical illness. These findings considerably change the view of obesity as a driver of serious, but slowly-progressing chronic diseases, and emphasize the urgency to explore new therapeutic approaches. Inflammation is a recognized driver of metabolic derangements in obesity and MetS, and a core feature of COVID-19 pathobiology. Recent advances in our understanding of inflammatory regulation have highlighted the role of the nervous system and the vagus nerve-based inflammatory reflex. Current bioelectronic and pharmacological therapeutic explorations centered on the inflammatory reflex offer new approaches for conditions characterized by immune and metabolic dysregulation and for ameliorating the escalating burden of obesity, MetS, and COVID-19. Twit Text FOAVip The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response ????Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=33310156 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33310156 #FOAvip English Wikipedia <ref>{{Cite pmid|33310156}}</ref> The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response #MMPMID33310156 Pavlov VA Pharmacol Ther 2021[Jun]; 222 (?): 107794 PMID33310156show ga Obesity and the metabolic syndrome (MetS), which have reached pandemic proportions significantly increase the risk for type 2 diabetes, cardiovascular disease, and other serious conditions. Recent data with COVID-19 patients indicate that obesity also is a significant risk factor for this novel viral disease and poor outcome of associated critical illness. These findings considerably change the view of obesity as a driver of serious, but slowly-progressing chronic diseases, and emphasize the urgency to explore new therapeutic approaches. Inflammation is a recognized driver of metabolic derangements in obesity and MetS, and a core feature of COVID-19 pathobiology. Recent advances in our understanding of inflammatory regulation have highlighted the role of the nervous system and the vagus nerve-based inflammatory reflex. Current bioelectronic and pharmacological therapeutic explorations centered on the inflammatory reflex offer new approaches for conditions characterized by immune and metabolic dysregulation and for ameliorating the escalating burden of obesity, MetS, and COVID-19. |*COVID-19/immunology/metabolism[MESH] |*Inflammation/immunology/metabolism[MESH] |*Obesity/epidemiology/immunology/therapy[MESH] |Humans[MESH] |Metabolic Syndrome/immunology[MESH] |SARS-CoV-2[MESH]The evolving obesity challenge: targeting the vagus nerve and the infl(epmc).pdf DeepDyve Pubget Overpricing