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10.1016/j.exger.2020.111197 http://scihub22266oqcxt.onion/10.1016/j.exger.2020.111197 33310152!7834182!33310152     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33310152&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Gerontol 2021 ; 145 (ä): 111197 Nephropedia Template TP {{tp|p=33310152|t=2021. Metformin in acute respiratory distress syndrome: An opinion |pdf=|usr=}}{{33310152}} gab.com Text Metformin in acute respiratory distress syndrome: An opinion JO: Exp Gerontol http://www.kidney.de/pget.php?&tw=1&pmid=33310152 #FOAvip Senior individuals are more susceptible to the irreversible outcomes of endothelial barrier dysfunction, the hallmark of Acute Respiratory Distress Syndrome (ARDS). The Severe Acute Respiratory Syndrome Coronovirus 2 (SARS-CoV-2) - inflicted ARDS delivers the devastating outcomes of the COVID-19 worldwide. Endothelial hyperpermeability has been associated with both the progression and establishment of the COVID-19 - related respiratory failure. In the present study we investigated the in vitro effects of Metformin in the permeability of bovine pulmonary artery endothelial cells. Our preliminary results suggest that moderate doses (0.1, 0.5, 1.0 mM) of this anti-diabetic agent enhance the vascular barrier integrity, since it produces an increase in the transendothelial resistance of endothelial monolayers. Thus, we speculate that Metformin may deliver a new therapeutic possibility in ARDS, alone or in combination with other barrier enhancers. Twit Text FOAVip Metformin in acute respiratory distress syndrome: An opinion ????Exp Gerontol http://www.kidney.de/pget.php?&tw=1&pmid=33310152 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33310152 #FOAvip English Wikipedia <ref>{{Cite pmid|33310152}}</ref> Metformin in acute respiratory distress syndrome: An opinion #MMPMID33310152 Uddin MA; Akhter MS; Kubra KT; Siejka A; Barabutis N Exp Gerontol 2021[Mar]; 145 (ä): 111197 PMID33310152show ga Senior individuals are more susceptible to the irreversible outcomes of endothelial barrier dysfunction, the hallmark of Acute Respiratory Distress Syndrome (ARDS). The Severe Acute Respiratory Syndrome Coronovirus 2 (SARS-CoV-2) - inflicted ARDS delivers the devastating outcomes of the COVID-19 worldwide. Endothelial hyperpermeability has been associated with both the progression and establishment of the COVID-19 - related respiratory failure. In the present study we investigated the in vitro effects of Metformin in the permeability of bovine pulmonary artery endothelial cells. Our preliminary results suggest that moderate doses (0.1, 0.5, 1.0 mM) of this anti-diabetic agent enhance the vascular barrier integrity, since it produces an increase in the transendothelial resistance of endothelial monolayers. Thus, we speculate that Metformin may deliver a new therapeutic possibility in ARDS, alone or in combination with other barrier enhancers. |Animals[MESH] |COVID-19[MESH] |Cattle[MESH] |Endothelial Cells/drug effects[MESH] |Humans[MESH] |Lung/drug effects[MESH] |Metformin/*therapeutic use[MESH] |Respiratory Distress Syndrome/*drug therapy[MESH]Metformin in acute respiratory distress syndrome: An opinion (epmc).pdf DeepDyve Pubget Overpricing