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10.1016/j.diabres.2020.108561

http://scihub22266oqcxt.onion/10.1016/j.diabres.2020.108561
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suck abstract from ncbi


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pmid33310127      Diabetes+Res+Clin+Pract 2021 ; 171 (ä): 108561
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  • High admission blood glucose independently predicts poor prognosis in COVID-19 patients: A systematic review and dose-response meta-analysis #MMPMID33310127
  • Lazarus G; Audrey J; Wangsaputra VK; Tamara A; Tahapary DL
  • Diabetes Res Clin Pract 2021[Jan]; 171 (ä): 108561 PMID33310127show ga
  • AIMS: To investigate the prognostic value of admission blood glucose (BG) in predicting COVID-19 outcomes, including poor composite outcomes (mortality/severity), mortality, and severity. METHODS: Eligible studies evaluating the association between admission fasting BG (FBG) and random BG (RBG) levels with COVID-19 outcomes were included and assessed for risk of bias with the Quality in Prognosis Studies tool. Random-effects dose-response meta-analysis was conducted to investigate potential linear or non-linear exposure-response gradient. RESULTS: The search yielded 35 studies involving a total of 14,502 patients. We discovered independent association between admission FBG and poor COVID-19 prognosis. Furthermore, we demonstrated non-linear relationship between admission FBG and severity (P(non-linearity) < 0.001), where each 1 mmol/L increase augmented the risk of severity by 33% (risk ratio 1.33 [95% CI: 1.26-1.40]). Albeit exhibiting similar trends, study scarcity limited the evidence strength on the independent prognostic value of admission RBG. GRADE assessment yielded high-quality evidence for the association between admission FBG and COVID-19 severity, and moderate-quality evidence for its association with mortality and poor outcomes. CONCLUSION: High admission FBG level independently predicted poor COVID-19 prognosis. Further research to confirm the prognostic value of admission RBG and to ascertain the estimated dose-response risk between admission FBG and COVID-19 severity are required.
  • |Blood Glucose/*analysis[MESH]
  • |COVID-19/complications/*mortality/transmission/virology[MESH]
  • |Diabetes Mellitus/epidemiology/metabolism/*mortality/virology[MESH]
  • |Humans[MESH]
  • |Hyperglycemia/*physiopathology[MESH]
  • |Prognosis[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/*isolation & purification[MESH]


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