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10.1016/j.lfs.2020.118877 http://scihub22266oqcxt.onion/10.1016/j.lfs.2020.118877 33310048!ä!33310048 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci 2021 ; 266 (ä): 118877 Nephropedia Template TP {{tp|p=33310048|t=2021. Sacubitril/valsartan treatment relieved the progression of established pulmonary hypertension in rat model and its mechanism |pdf=|usr=}}{{33310048}} gab.com Text Sacubitril/valsartan treatment relieved the progression of established pulmonary hypertension in rat model and its mechanism JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33310048 #FOAvip AIMS: Pulmonary hypertension (PH) is a fatal disease identified by progressive elevated pulmonary arterial pressure, which neurohormonal activation is a notable contributor to its development. Sacubitril/valsartan is a complex of sacubitril [via enhancing the natriuretic peptide (NP) system] and valsartan [via blocking the renin-angiotensin-aldosterone system (RAAS)]. Regulation of the two neurohormonal system had been shown to attenuate PH. This study was to explore the role of sacubitril/valsartan in both monocrotaline (MCT)-induced and hypoxia-induced rat models and the underlying mechanism. MAIN METHODS: The rats were treated with MCT or hypoxic environment for 14 days, after that sacubitril/valsartan were given for another 14 days. Hemodynamic measurements and histological assessments were performed. The expression of NPs was measured using RT-PCR and ELISA, while the protein level of natriuretic peptide receptors (NPRs) and AT1 receptor were detected by western blot, the concentrations of cGMP, IL-1beta, IL-6, TNF-alpha and TGF-beta1 were tested by ELISA. KEY FINDINGS: We found that sacubitril/valsartan significantly improved the hemodynamic and histological data of two PH models. Sacubitril/valsartan suppressed the protein expression of AT1 receptor (P < 0.05). The intervention increased the expression of ANP and CNP (P< 0.05) and therefore upregulated the protein expression of NPRs (P < 0.05), raised the concentration of cGMP (P < 0.05). In addition, the treatment reduced the concentration of IL-1beta, IL-6 and TNF-alpha (P < 0.05) but have no effects on TGF-beta1. SIGNIFICANCE: Sacubitril/valsartan alleviated PH in MCT-induced and hypoxia-induced rat models by inhibiting the activated RAAS, promoting ANP/NPR-A/cGMP and CNP/NPR-B/cGMP pathway, restoring the NPR-C signaling and the anti-inflammatory effects. Twit Text FOAVip Sacubitril/valsartan treatment relieved the progression of established pulmonary hypertension in rat model and its mechanism ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33310048 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33310048 #FOAvip English Wikipedia <ref>{{Cite pmid|33310048}}</ref> Sacubitril/valsartan treatment relieved the progression of established pulmonary hypertension in rat model and its mechanism #MMPMID33310048 Liu S; Wang Y; Lu S; Hu J; Zeng X; Liu W; Wang Y; Wang Z Life Sci 2021[Feb]; 266 (ä): 118877 PMID33310048show ga AIMS: Pulmonary hypertension (PH) is a fatal disease identified by progressive elevated pulmonary arterial pressure, which neurohormonal activation is a notable contributor to its development. Sacubitril/valsartan is a complex of sacubitril [via enhancing the natriuretic peptide (NP) system] and valsartan [via blocking the renin-angiotensin-aldosterone system (RAAS)]. Regulation of the two neurohormonal system had been shown to attenuate PH. This study was to explore the role of sacubitril/valsartan in both monocrotaline (MCT)-induced and hypoxia-induced rat models and the underlying mechanism. MAIN METHODS: The rats were treated with MCT or hypoxic environment for 14 days, after that sacubitril/valsartan were given for another 14 days. Hemodynamic measurements and histological assessments were performed. The expression of NPs was measured using RT-PCR and ELISA, while the protein level of natriuretic peptide receptors (NPRs) and AT1 receptor were detected by western blot, the concentrations of cGMP, IL-1beta, IL-6, TNF-alpha and TGF-beta1 were tested by ELISA. KEY FINDINGS: We found that sacubitril/valsartan significantly improved the hemodynamic and histological data of two PH models. Sacubitril/valsartan suppressed the protein expression of AT1 receptor (P < 0.05). The intervention increased the expression of ANP and CNP (P< 0.05) and therefore upregulated the protein expression of NPRs (P < 0.05), raised the concentration of cGMP (P < 0.05). In addition, the treatment reduced the concentration of IL-1beta, IL-6 and TNF-alpha (P < 0.05) but have no effects on TGF-beta1. SIGNIFICANCE: Sacubitril/valsartan alleviated PH in MCT-induced and hypoxia-induced rat models by inhibiting the activated RAAS, promoting ANP/NPR-A/cGMP and CNP/NPR-B/cGMP pathway, restoring the NPR-C signaling and the anti-inflammatory effects. |*Disease Models, Animal[MESH] |Aminobutyrates/*pharmacology[MESH] |Angiotensin Receptor Antagonists/*pharmacology[MESH] |Animals[MESH] |Biphenyl Compounds[MESH] |Body Weight[MESH] |Disease Progression[MESH] |Drug Combinations[MESH] |Hypertension, Pulmonary/etiology/pathology/*prevention & control[MESH] |Hypoxia/*physiopathology[MESH] |Male[MESH] |Monocrotaline/*toxicity[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Tetrazoles/*pharmacology[MESH]Sacubitril/valsartan treatment relieved the progression of established(epmc).pdf DeepDyve Pubget Overpricing