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  • Potential SARS-CoV-2 main protease inhibitors #MMPMID33309533
  • Banerjee R; Perera L; Tillekeratne LMV
  • Drug Discov Today 2021[Mar]; 26 (3): 804-816 PMID33309533show ga
  • The coronavirus disease 2019 (COVID-19) pandemic has prompted an urgent need for new treatment strategies. No target-specific drugs are currently available for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but new drug candidates targeting the viral replication cycle are being explored. A prime target of drug-discovery efforts is the SARS-CoV-2 main protease (M(pro)). The main proteases of different coronaviruses, including SARS-CoV-2, SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), share a structurally conserved substrate-binding region that can be exploited to design new protease inhibitors. With the recent reporting of the X-ray crystal structure of the SARS-CoV-2 M(pro), studies to discover M(pro) inhibitors using both virtual and in vitro screening are progressing rapidly. This review focusses on the recent developments in the search for small-molecule inhibitors targeting the SARS-CoV-2 M(pro).
  • |*Coronavirus 3C Proteases/antagonists & inhibitors/chemistry/metabolism[MESH]
  • |*SARS-CoV-2/drug effects/physiology[MESH]
  • |COVID-19/*drug therapy[MESH]
  • |Drug Design[MESH]
  • |Drug Discovery/*methods[MESH]
  • |Humans[MESH]
  • |Virus Replication/drug effects[MESH]

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  • suck abstract from ncbi

    804 3.26 2021