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SARS-CoV-2: como es, como actua y como se expresa en la imagen #MMPMID33309398
Fernandez-Perez GC; Onate Miranda M; Fernandez-Rodriguez P; Velasco Casares M; Corral de la Calle M; Franco Lopez A; Diez Blanco M; Cuchat JMO
Radiologia (Engl Ed) 2021[Mar]; 63 (2): 115-126 PMID33309398show ga
COVID-19 is a disease with many clinical, biochemical, and radiological signs that has a predilection for the lungs, probably because of the high number of ACE-2 receptors in this organ. The infection of cells activates proinflammatory substances, causing diffuse alveolar damage, which is the histopathological basis of ARDS. The exudative phase would manifest as ground-glass opacities and consolidation, and the proliferative phase would manifest as a tendency toward a more linear morphology. Both CT and PET/CT findings support the inflammatory character of the lung lesions in the initial phase of the disease and in patients with mild-moderate disease. Severe cases have pulmonary hypoperfusion that is likely due to abnormal alveolar ventilation and perfusion. On the other hand, a prothrombotic state increases the risk of thromboembolic disease through the activation of coagulation and platelet pathways with the production of fibrin degradation products (D-dimer) and consumption of platelets.