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10.1016/j.jgar.2020.11.025

http://scihub22266oqcxt.onion/10.1016/j.jgar.2020.11.025
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33307276!7722492!33307276
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suck abstract from ncbi


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pmid33307276      J+Glob+Antimicrob+Resist 2021 ; 24 (ä): 45-47
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  • A point prevalence survey to assess antibiotic prescribing in patients hospitalized with confirmed and suspected coronavirus disease 2019 (COVID-19) #MMPMID33307276
  • Tan SH; Ng TM; Tay HL; Yap MY; Heng ST; Loo AYX; Teng CB; Lee TH
  • J Glob Antimicrob Resist 2021[Mar]; 24 (ä): 45-47 PMID33307276show ga
  • BACKGROUND: Earlier studies have reported high antibiotic use in patients hospitalised for coronavirus disease 2019 (COVID-19), resulting in concerns of increasing antimicrobial resistance with increase antibiotic use in this pandemic. Point prevalence survey (PPS) can be a quick tool to provide antibiotic prescribing information to aid antimicrobial stewardship (AMS) activities. OBJECTIVES: To describe antibiotic utilization and evaluate antibiotic appropriateness in COVID-19 patients using PPS. METHODS: Adapting Global-PPS on antimicrobial use, the survey was conducted in COVID-19 wards at 2 centres in Singapore on 22 April 2020 at 0800h. Patients on systemic antibiotics were included and evaluated for antibiotic appropriateness. RESULTS: Five hundred and seventy-seven patients were screened. Thirty-six (6.2%) patients were on antibiotics and which were started at median of 7 days (inter-quartile rate (IQR), 4, 11) from symptom onset. Fifty-one antibiotics were prescribed in these patients. Overall, co-amoxiclav (26/51, 51.0%) was the most often prescribed antibiotic. Thirty-one out of 51 (60.8%) antibiotic prescriptions were appropriate. Among 20 inappropriate prescriptions, 18 (90.0%) were initiated in patients with low likelihood of bacterial infections. Antibiotic prescriptions were more appropriate when reviewed by infectious diseases physicians (13/31 [41.9%] versus 2/20 [10.0%], p=0.015), and if reasons for use were stated in notes (31/31 [100.0%] versus 16/20 [80.0%], p=0.019). CONCLUSIONS: Despite low prevalence of antibiotic use among confirmed and suspected COVID-19 patients at 2 centres in Singapore, there was significant proportion of inappropriate antibiotics use where bacterial infections were unlikely. AMS teams can tailor stewardship strategies using PPS results.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Anti-Bacterial Agents/*therapeutic use[MESH]
  • |Antibiotic Prophylaxis/statistics & numerical data[MESH]
  • |Antimicrobial Stewardship[MESH]
  • |Bacterial Infections/*drug therapy/microbiology/virology[MESH]
  • |COVID-19/diagnosis/*epidemiology/*microbiology[MESH]
  • |Drug Prescriptions/statistics & numerical data[MESH]
  • |Drug Resistance, Bacterial[MESH]
  • |Female[MESH]
  • |Hospitals/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Inappropriate Prescribing/*statistics & numerical data[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Practice Patterns, Physicians'/statistics & numerical data[MESH]
  • |Prevalence[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Singapore/epidemiology[MESH]


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