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10.3389/fncel.2020.592214 http://scihub22266oqcxt.onion/10.3389/fncel.2020.592214 33304243!7693550!33304243     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33304243.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Cell+Neurosci 2020 ; 14 (ä): 592214 Nephropedia Template TP {{tp|p=33304243|t=2020. Neuropathobiology of COVID-19: The Role for Glia |pdf=|usr=}}{{33304243}} gab.com Text Neuropathobiology of COVID-19: The Role for Glia JO: Front Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=33304243 #FOAvip SARS-CoV-2, which causes the Coronavirus Disease 2019 (COVID-19) pandemic, has a brain neurotropism through binding to the receptor angiotensin-converting enzyme 2 expressed by neurones and glial cells, including astrocytes and microglia. Systemic infection which accompanies severe cases of COVID-19 also triggers substantial increase in circulating levels of chemokines and interleukins that compromise the blood-brain barrier, enter the brain parenchyma and affect its defensive systems, astrocytes and microglia. Brain areas devoid of a blood-brain barrier such as the circumventricular organs are particularly vulnerable to circulating inflammatory mediators. The performance of astrocytes and microglia, as well as of immune cells required for brain health, is considered critical in defining the neurological damage and neurological outcome of COVID-19. In this review, we discuss the neurotropism of SARS-CoV-2, the implication of neuroinflammation, adaptive and innate immunity, autoimmunity, as well as astrocytic and microglial immune and homeostatic functions in the neurological and psychiatric aspects of COVID-19. The consequences of SARS-CoV-2 infection during ageing, in the presence of systemic comorbidities, and for the exposed pregnant mother and foetus are also covered. Twit Text FOAVip Neuropathobiology of COVID-19: The Role for Glia ????Front Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=33304243 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33304243 #FOAvip English Wikipedia <ref>{{Cite pmid|33304243}}</ref> Neuropathobiology of COVID-19: The Role for Glia #MMPMID33304243 Tremblay ME; Madore C; Bordeleau M; Tian L; Verkhratsky A Front Cell Neurosci 2020[]; 14 (ä): 592214 PMID33304243show ga SARS-CoV-2, which causes the Coronavirus Disease 2019 (COVID-19) pandemic, has a brain neurotropism through binding to the receptor angiotensin-converting enzyme 2 expressed by neurones and glial cells, including astrocytes and microglia. Systemic infection which accompanies severe cases of COVID-19 also triggers substantial increase in circulating levels of chemokines and interleukins that compromise the blood-brain barrier, enter the brain parenchyma and affect its defensive systems, astrocytes and microglia. Brain areas devoid of a blood-brain barrier such as the circumventricular organs are particularly vulnerable to circulating inflammatory mediators. The performance of astrocytes and microglia, as well as of immune cells required for brain health, is considered critical in defining the neurological damage and neurological outcome of COVID-19. In this review, we discuss the neurotropism of SARS-CoV-2, the implication of neuroinflammation, adaptive and innate immunity, autoimmunity, as well as astrocytic and microglial immune and homeostatic functions in the neurological and psychiatric aspects of COVID-19. The consequences of SARS-CoV-2 infection during ageing, in the presence of systemic comorbidities, and for the exposed pregnant mother and foetus are also covered. äNeuropathobiology of COVID-19: The Role for Glia (epmc).pdf DeepDyve Pubget Overpricing