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10.1126/science.abe3261

http://scihub22266oqcxt.onion/10.1126/science.abe3261
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33303686!7857412!33303686
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suck abstract from ncbi


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pmid33303686      Science 2021 ; 371 (6529): ä
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  • Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events #MMPMID33303686
  • Lemieux JE; Siddle KJ; Shaw BM; Loreth C; Schaffner SF; Gladden-Young A; Adams G; Fink T; Tomkins-Tinch CH; Krasilnikova LA; DeRuff KC; Rudy M; Bauer MR; Lagerborg KA; Normandin E; Chapman SB; Reilly SK; Anahtar MN; Lin AE; Carter A; Myhrvold C; Kemball ME; Chaluvadi S; Cusick C; Flowers K; Neumann A; Cerrato F; Farhat M; Slater D; Harris JB; Branda JA; Hooper D; Gaeta JM; Baggett TP; O'Connell J; Gnirke A; Lieberman TD; Philippakis A; Burns M; Brown CM; Luban J; Ryan ET; Turbett SE; LaRocque RC; Hanage WP; Gallagher GR; Madoff LC; Smole S; Pierce VM; Rosenberg E; Sabeti PC; Park DJ; MacInnis BL
  • Science 2021[Feb]; 371 (6529): ä PMID33303686show ga
  • Analysis of 772 complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from early in the Boston-area epidemic revealed numerous introductions of the virus, a small number of which led to most cases. The data revealed two superspreading events. One, in a skilled nursing facility, led to rapid transmission and significant mortality in this vulnerable population but little broader spread, whereas other introductions into the facility had little effect. The second, at an international business conference, produced sustained community transmission and was exported, resulting in extensive regional, national, and international spread. The two events also differed substantially in the genetic variation they generated, suggesting varying transmission dynamics in superspreading events. Our results show how genomic epidemiology can help to understand the link between individual clusters and wider community spread.
  • |*Genome, Viral[MESH]
  • |*Phylogeny[MESH]
  • |Boston/epidemiology[MESH]
  • |COVID-19/*epidemiology/transmission[MESH]
  • |Disease Outbreaks[MESH]
  • |Epidemiological Monitoring[MESH]
  • |Humans[MESH]


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  • suck abstract from ncbi

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