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10.1016/j.rmed.2020.106272

http://scihub22266oqcxt.onion/10.1016/j.rmed.2020.106272
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33302142!7701891!33302142
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suck abstract from ncbi


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pmid33302142      Respir+Med 2021 ; 176 (ä): 106272
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  • Pulmonary function and health-related quality of life after COVID-19 pneumonia #MMPMID33302142
  • van der Sar-van der Brugge S; Talman S; Boonman-de Winter L; de Mol M; Hoefman E; van Etten RW; De Backer IC
  • Respir Med 2021[Jan]; 176 (ä): 106272 PMID33302142show ga
  • BACKGROUND: The COVID-19 pandemic has led to many cases of pneumonia with extensive lung abnormalities on CT-scans. The consequences of COVID-19 pneumonia on survivors' pulmonary function and quality of life are unknown. The purpose of this study is to examine the impact of COVID-19 pneumonia on pulmonary function, health-related quality of life (HRQoL) and perceived dyspnoea. METHODS: A prospective longitudinal cohort study regarding patients discharged from our hospital after PCR-proven, non-critical COVID-19 pneumonia was conducted. Cases were classified as moderate or severe pneumonia according to WHO definitions. Six weeks post-discharge subjects underwent interviews and pulmonary function tests, and completed questionnaires to assess their HRQoL, perceived dyspnoea (Borgscale and mMRC), and symptoms of depression and anxiety (HADS). RESULTS: 101 patients were included. Twenty-eight (27.7%) pneumonias were classified as moderate cases of COVID-19 pneumonia and 73 (72.3%) were classified as severe cases. Diffusion limitation (DLCOc < 80% of predicted value) was found in 66 (71.7%) of 92 cases, obstruction in 26 (25.7%) of 101, and restriction in 21 (21.2%) of 99. Diffusion capacity was significantly lower in cases after severe pneumonia. In the entire group, HADS scores >/=8 for depression were found in 16.6% and in 12.5% for anxiety. Across all SF-36 domains, except for bodily pain, significant impairment was found. FEV1 and DLCOc showed significant positive correlations with mMRC scores and multiple SF-36 domains, especially physical functioning. CONCLUSION: COVID-19 non-critical pneumonia survivors have significant impairment in diffusion capacity and HRQOL six weeks after being discharged from hospital.
  • |*Quality of Life[MESH]
  • |Aged[MESH]
  • |COVID-19/complications/*physiopathology/*psychology[MESH]
  • |Dyspnea/physiopathology/psychology/virology[MESH]
  • |Female[MESH]
  • |Health Status[MESH]
  • |Humans[MESH]
  • |Longitudinal Studies[MESH]
  • |Lung/*physiopathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Netherlands[MESH]
  • |Prospective Studies[MESH]
  • |Respiratory Function Tests[MESH]


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