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10.1002/jmv.26720 http://scihub22266oqcxt.onion/10.1002/jmv.26720 33300152!7897247!33300152     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (4): 1983-1998 Nephropedia Template TP {{tp|p=33300152|t=2021. Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID-19 |pdf=|usr=}}{{33300152}} gab.com Text Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID-19 JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33300152 #FOAvip Patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection manifest mainly respiratory symptoms. However, clinical observations frequently identified neurological symptoms and neuropsychiatric disorders related to COVID-19 (Neuro-SARS2). Accumulated robust evidence indicates that Neuro-SARS2 may play an important role in aggravating the disease severity and mortality. Understanding the neuropathogenesis and cellular mechanisms underlying Neuro-SARS2 is crucial for both basic research and clinical practice to establish effective strategies for early detection/diagnosis, prevention, and treatment. In this review, we comprehensively examine current evidence of SARS-CoV-2 infection in various neural cells including neurons, microglia/macrophages, astrocytes, pericytes/endothelial cells, ependymocytes/choroid epithelial cells, and neural stem/progenitor cells. Although significant progress has been made in studying Neuro-SARS2, much remains to be learned about the neuroinvasive routes (transneuronal and hematogenous) of the virus and the cellular/molecular mechanisms underlying the development/progression of this disease. Future and ongoing studies require the establishment of more clinically relevant and suitable neural cell models using human induced pluripotent stem cells, brain organoids, and postmortem specimens. Twit Text FOAVip Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID-19 ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33300152 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33300152 #FOAvip English Wikipedia <ref>{{Cite pmid|33300152}}</ref> Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID-19 #MMPMID33300152 Bodnar B; Patel K; Ho W; Luo JJ; Hu W J Med Virol 2021[Apr]; 93 (4): 1983-1998 PMID33300152show ga Patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection manifest mainly respiratory symptoms. However, clinical observations frequently identified neurological symptoms and neuropsychiatric disorders related to COVID-19 (Neuro-SARS2). Accumulated robust evidence indicates that Neuro-SARS2 may play an important role in aggravating the disease severity and mortality. Understanding the neuropathogenesis and cellular mechanisms underlying Neuro-SARS2 is crucial for both basic research and clinical practice to establish effective strategies for early detection/diagnosis, prevention, and treatment. In this review, we comprehensively examine current evidence of SARS-CoV-2 infection in various neural cells including neurons, microglia/macrophages, astrocytes, pericytes/endothelial cells, ependymocytes/choroid epithelial cells, and neural stem/progenitor cells. Although significant progress has been made in studying Neuro-SARS2, much remains to be learned about the neuroinvasive routes (transneuronal and hematogenous) of the virus and the cellular/molecular mechanisms underlying the development/progression of this disease. Future and ongoing studies require the establishment of more clinically relevant and suitable neural cell models using human induced pluripotent stem cells, brain organoids, and postmortem specimens. |Animals[MESH] |Brain/pathology/*virology[MESH] |COVID-19/*pathology[MESH] |Cell Line[MESH] |Humans[MESH] |Nervous System Diseases/pathology/*virology[MESH] |Neural Stem Cells[MESH] |Neuroglia/pathology/*virology[MESH]Cellular mechanisms underlying neurological/neuropsychiatric manifesta(epmc).pdf DeepDyve Pubget Overpricing