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10.1101/2020.12.04.412155 http://scihub22266oqcxt.onion/10.1101/2020.12.04.412155 33300002!7724678!33300002     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       bioRxiv 2020 ; ä (ä): ä Nephropedia Template TP {{tp|p=33300002|t=2020. Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity |pdf=|usr=}}{{33300002}} gab.com Text Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity JO: bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=33300002 #FOAvip SARS-CoV-2 infection triggers highly variable host responses and causes varying degrees of illness in humans. We sought to harness the peripheral blood mononuclear cell (PBMC) response over the course of illness to provide insight into COVID-19 physiology. We analyzed PBMCs from subjects with variable symptom severity at different stages of clinical illness before and after IgG seroconversion to SARS-CoV-2. Prior to seroconversion, PBMC transcriptomes did not distinguish symptom severity. In contrast, changes in chromatin accessibility were associated with symptom severity. Furthermore, single-cell analyses revealed evolution of the chromatin accessibility landscape and transcription factor motif occupancy for individual PBMC cell types. The most extensive remodeling occurred in CD14+ monocytes where sub-populations with distinct chromatin accessibility profiles were associated with disease severity. Our findings indicate that pre-seroconversion chromatin remodeling in certain innate immune populations is associated with divergence in symptom severity, and the identified transcription factors, regulatory elements, and downstream pathways provide potential prognostic markers for COVID-19 subjects. Twit Text FOAVip Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity ????bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=33300002 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33300002 #FOAvip English Wikipedia <ref>{{Cite pmid|33300002}}</ref> Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity #MMPMID33300002 Giroux NS; Ding S; McClain MT; Burke TW; Petzold E; Chung HA; Palomino GR; Wang E; Xi R; Bose S; Rotstein T; Nicholson BP; Chen T; Henao R; Sempowski GD; Denny TN; Ko ER; Ginsburg GS; Kraft BD; Tsalik EL; Woods CW; Shen X bioRxiv 2020[Dec]; ä (ä): ä PMID33300002show ga SARS-CoV-2 infection triggers highly variable host responses and causes varying degrees of illness in humans. We sought to harness the peripheral blood mononuclear cell (PBMC) response over the course of illness to provide insight into COVID-19 physiology. We analyzed PBMCs from subjects with variable symptom severity at different stages of clinical illness before and after IgG seroconversion to SARS-CoV-2. Prior to seroconversion, PBMC transcriptomes did not distinguish symptom severity. In contrast, changes in chromatin accessibility were associated with symptom severity. Furthermore, single-cell analyses revealed evolution of the chromatin accessibility landscape and transcription factor motif occupancy for individual PBMC cell types. The most extensive remodeling occurred in CD14+ monocytes where sub-populations with distinct chromatin accessibility profiles were associated with disease severity. Our findings indicate that pre-seroconversion chromatin remodeling in certain innate immune populations is associated with divergence in symptom severity, and the identified transcription factors, regulatory elements, and downstream pathways provide potential prognostic markers for COVID-19 subjects. äChromatin remodeling in peripheral blood cells reflects COVID-19 sympt(epmc).pdf DeepDyve Pubget Overpricing