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10.1101/2020.07.22.202275 http://scihub22266oqcxt.onion/10.1101/2020.07.22.202275 33299992!7724660!33299992     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       bioRxiv 2020 ; ä (ä): ä Nephropedia Template TP {{tp|p=33299992|t=2020. Transcriptional response modules characterise IL-1beta and IL-6 activity in COVID-19 |pdf=|usr=}}{{33299992}} gab.com Text Transcriptional response modules characterise IL-1beta and IL-6 activity in COVID-19 JO: bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=33299992 #FOAvip Dysregulated IL-1beta and IL-6 responses have been implicated in the pathogenesis of severe Coronavirus Disease 2019 (COVID-19). Innovative approaches for evaluating the biological activity of these cytokines in vivo are urgently needed to complement clinical trials of therapeutic targeting of IL-1beta and IL-6 in COVID-19. We show that the expression of IL-1beta or IL-6 inducible transcriptional signatures (modules) reflects the bioactivity of these cytokines in immunopathology modelled by juvenile idiopathic arthritis (JIA) and rheumatoid arthritis. In COVID-19, elevated expression of IL-1beta and IL-6 response modules, but not the cytokine transcripts themselves, is a feature of infection in the nasopharynx and blood, but is not associated with severity of COVID-19 disease, length of stay or mortality. We propose that IL-1beta and IL-6 transcriptional response modules provide a dynamic readout of functional cytokine activity in vivo, aiding quantification of the biological effects of immunomodulatory therapies in COVID-19. Twit Text FOAVip Transcriptional response modules characterise IL-1beta and IL-6 activity in COVID-19 ????bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=33299992 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33299992 #FOAvip English Wikipedia <ref>{{Cite pmid|33299992}}</ref> Transcriptional response modules characterise IL-1beta and IL-6 activity in COVID-19 #MMPMID33299992 Bell LC; Meydan C; Kim J; Foox J; Butler D; Mason CE; Shapira SD; Noursadeghi M; Pollara G bioRxiv 2020[Dec]; ä (ä): ä PMID33299992show ga Dysregulated IL-1beta and IL-6 responses have been implicated in the pathogenesis of severe Coronavirus Disease 2019 (COVID-19). Innovative approaches for evaluating the biological activity of these cytokines in vivo are urgently needed to complement clinical trials of therapeutic targeting of IL-1beta and IL-6 in COVID-19. We show that the expression of IL-1beta or IL-6 inducible transcriptional signatures (modules) reflects the bioactivity of these cytokines in immunopathology modelled by juvenile idiopathic arthritis (JIA) and rheumatoid arthritis. In COVID-19, elevated expression of IL-1beta and IL-6 response modules, but not the cytokine transcripts themselves, is a feature of infection in the nasopharynx and blood, but is not associated with severity of COVID-19 disease, length of stay or mortality. We propose that IL-1beta and IL-6 transcriptional response modules provide a dynamic readout of functional cytokine activity in vivo, aiding quantification of the biological effects of immunomodulatory therapies in COVID-19. äTranscriptional response modules characterise IL-1beta and IL-6 activi(epmc).pdf DeepDyve Pubget Overpricing