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10.1155/2020/8632048 http://scihub22266oqcxt.onion/10.1155/2020/8632048 33299899!7709498!33299899     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol+Res 2020 ; 2020 (ä): 8632048 Nephropedia Template TP {{tp|p=33299899|t=2020. Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS-CoV-2 |pdf=|usr=}}{{33299899}} gab.com Text Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS-CoV-2 JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=33299899 #FOAvip Novel coronavirus disease 2019 (COVID-19) causes pulmonary and cardiovascular disorders and has become a worldwide emergency. Myocardial injury can be caused by direct or indirect damage, particularly mediated by a cytokine storm, a disordered immune response that can cause myocarditis, abnormal coagulation, arrhythmia, acute coronary syndrome, and myocardial infarction. The present review focuses on the mechanisms of this viral infection, cardiac biomarkers, consequences, and the possible therapeutic role of purinergic and adenosinergic signalling systems. In particular, we focus on the interaction of the extracellular nucleotide adenosine triphosphate (ATP) with its receptors P2X1, P2X4, P2X7, P2Y1, and P2Y2 and of adenosine (Ado) with A2A and A3 receptors, as well as their roles in host immune responses. We suggest that receptors of purinergic signalling could be ideal candidates for pharmacological targeting to protect against myocardial injury caused by a cytokine storm in COVID-19, in order to reduce systemic inflammatory damage to cells and tissues, preventing the progression of the disease by modulating the immune response and improving patient quality of life. Twit Text FOAVip Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS-CoV-2 ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=33299899 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33299899 #FOAvip English Wikipedia <ref>{{Cite pmid|33299899}}</ref> Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS-CoV-2 #MMPMID33299899 Dos Anjos F; Simoes JLB; Assmann CE; Carvalho FB; Bagatini MD J Immunol Res 2020[]; 2020 (ä): 8632048 PMID33299899show ga Novel coronavirus disease 2019 (COVID-19) causes pulmonary and cardiovascular disorders and has become a worldwide emergency. Myocardial injury can be caused by direct or indirect damage, particularly mediated by a cytokine storm, a disordered immune response that can cause myocarditis, abnormal coagulation, arrhythmia, acute coronary syndrome, and myocardial infarction. The present review focuses on the mechanisms of this viral infection, cardiac biomarkers, consequences, and the possible therapeutic role of purinergic and adenosinergic signalling systems. In particular, we focus on the interaction of the extracellular nucleotide adenosine triphosphate (ATP) with its receptors P2X1, P2X4, P2X7, P2Y1, and P2Y2 and of adenosine (Ado) with A2A and A3 receptors, as well as their roles in host immune responses. We suggest that receptors of purinergic signalling could be ideal candidates for pharmacological targeting to protect against myocardial injury caused by a cytokine storm in COVID-19, in order to reduce systemic inflammatory damage to cells and tissues, preventing the progression of the disease by modulating the immune response and improving patient quality of life. |*SARS-CoV-2[MESH] |Adenosine A2 Receptor Agonists/pharmacology[MESH] |Adenosine Triphosphate/*metabolism[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*immunology/metabolism[MESH] |Cardiovascular Diseases/immunology/physiopathology/*virology[MESH] |Cytokines/metabolism[MESH] |Humans[MESH] |Myocardial Ischemia/immunology/physiopathology/virology[MESH] |Pandemics[MESH] |Purinergic Antagonists/pharmacology[MESH] |Receptor, Adenosine A2A/metabolism[MESH] |Receptor, Adenosine A3/metabolism[MESH] |Receptors, Purinergic/*metabolism[MESH]Potential Therapeutic Role of Purinergic Receptors in Cardiovascular D(epmc).pdf DeepDyve Pubget Overpricing