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10.1038/s41374-020-00520-2 http://scihub22266oqcxt.onion/10.1038/s41374-020-00520-2 33299126!7724622!33299126     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lab+Invest 2021 ; 101 (3): 274-279 Nephropedia Template TP {{tp|p=33299126|t=2021. COVID-19 and graft-versus-host disease: a tale of two diseases (and why age matters) |pdf=|usr=}}{{33299126}} gab.com Text COVID-19 and graft-versus-host disease: a tale of two diseases (and why age matters) JO: Lab Invest http://www.kidney.de/pget.php?&tw=1&pmid=33299126 #FOAvip Disorders involving injury to tissue stem cells that ensure normal tissue homeostasis and repair have potential to show unusually devastating clinical consequences. Acute graft-versus-host disease (aGVHD) is one condition where relatively few cytotoxic immune cells target skin stem cells to produce significant morbidity and mortality. By analogy, SARS-CoV-2 is a vector that initially homes to pulmonary stem cells that preferentially express the ACE2 receptor, thus potentially incurring similarly robust pathological consequences. In older individuals, stem cell number and/or function become depleted due to pathways independent of disease-related injury to these subpopulations. Accordingly, pathologic targeting of stem cells in conditions like aGVHD and COVID-19 infection where these cells are already deficient due to the aging process may have dire consequences in elderly individuals. A hypothesis is herein advanced that, as with aGVHD, lung stem cell targeting is a potential co-factor in explaining age-related severity of COVID-19 infection. Twit Text FOAVip COVID-19 and graft-versus-host disease: a tale of two diseases (and why age matters) ????Lab Invest http://www.kidney.de/pget.php?&tw=1&pmid=33299126 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33299126 #FOAvip English Wikipedia <ref>{{Cite pmid|33299126}}</ref> COVID-19 and graft-versus-host disease: a tale of two diseases (and why age matters) #MMPMID33299126 Murphy GF Lab Invest 2021[Mar]; 101 (3): 274-279 PMID33299126show ga Disorders involving injury to tissue stem cells that ensure normal tissue homeostasis and repair have potential to show unusually devastating clinical consequences. Acute graft-versus-host disease (aGVHD) is one condition where relatively few cytotoxic immune cells target skin stem cells to produce significant morbidity and mortality. By analogy, SARS-CoV-2 is a vector that initially homes to pulmonary stem cells that preferentially express the ACE2 receptor, thus potentially incurring similarly robust pathological consequences. In older individuals, stem cell number and/or function become depleted due to pathways independent of disease-related injury to these subpopulations. Accordingly, pathologic targeting of stem cells in conditions like aGVHD and COVID-19 infection where these cells are already deficient due to the aging process may have dire consequences in elderly individuals. A hypothesis is herein advanced that, as with aGVHD, lung stem cell targeting is a potential co-factor in explaining age-related severity of COVID-19 infection. |*SARS-CoV-2/pathogenicity[MESH] |Age Factors[MESH] |Aging/immunology/pathology[MESH] |COVID-19/*etiology/immunology/pathology[MESH] |Graft vs Host Disease/*etiology/immunology/pathology[MESH] |Humans[MESH] |Lung/immunology/pathology[MESH] |Models, Biological[MESH] |Risk Factors[MESH] |Skin/immunology/pathology[MESH]COVID-19 and graft-versus-host disease: a tale of two diseases (and wh(epmc).pdf DeepDyve Pubget Overpricing