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10.1371/journal.pone.0243528 http://scihub22266oqcxt.onion/10.1371/journal.pone.0243528 33296419!7725289!33296419     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33296419&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       PLoS+One 2020 ; 15 (12): e0243528 Nephropedia Template TP {{tp|p=33296419|t=2020. Severe acute kidney injury in COVID-19 patients is associated with in-hospital mortality |pdf=|usr=}}{{33296419}} gab.com Text Severe acute kidney injury in COVID-19 patients is associated with in-hospital mortality JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33296419 #FOAvip Although the lungs are major targets for COVID-19 invasion, other organs-such as the kidneys-are also affected. However, the renal complications of COVID-19 are not yet well explored. This study aimed to identify the incidence of acute kidney injury (AKI) in patients with COVID-19 and to evaluate its impact on patient outcomes. This retrospective study included 704 patients with COVID-19 who were hospitalized at two hospitals in Daegu, Korea from February 19 to March 31, 2020. AKI was defined according to the serum creatinine criteria in the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. The final date of follow-up was May 1, 2020. Of the 704 patients, 28 (4.0%) developed AKI. Of the 28 patients with AKI, 15 (53.6%) were found to have AKI stage 1, 3 (10.7%) had AKI stage 2, and 10 (35.7%) had AKI stage 3. Among these patients, 12 (42.9%) recovered from AKI. In the patients with AKI, the rates of admission to intensive care unit (ICU), administration of mechanical ventilator (MV), and in-hospital mortality were significantly higher than in patients without AKI. Multivariable analysis revealed that old age (Hazard ratio [HR] = 4.668, 95% confidence interval [CI] = 1.250-17.430, p = 0.022), high neutrophil-to-lymphocyte ratio (HR = 1.167, 95% CI = 1.078-1.264, p < 0.001), elevated creatinine kinase (HR = 1.002, 95% CI = 1.001-1.004, p = 0.007), and severe AKI (HR = 12.199, 95% CI = 4.235-35.141, p < 0.001) were independent risk factors for in-hospital mortality. The Kaplan-Meier curves showed that the cumulative survival rate was lowest in the AKI stage 3 group (p < 0.001). In conclusion, the incidence of AKI in patients with COVID-19 was 4.0%. Severe AKI was associated with in-hospital death. Twit Text FOAVip Severe acute kidney injury in COVID-19 patients is associated with in-hospital mortality ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33296419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33296419 #FOAvip English Wikipedia <ref>{{Cite pmid|33296419}}</ref> Severe acute kidney injury in COVID-19 patients is associated with in-hospital mortality #MMPMID33296419 Paek JH; Kim Y; Park WY; Jin K; Hyun M; Lee JY; Kim HA; Kwon YS; Park JS; Han S PLoS One 2020[]; 15 (12): e0243528 PMID33296419show ga Although the lungs are major targets for COVID-19 invasion, other organs-such as the kidneys-are also affected. However, the renal complications of COVID-19 are not yet well explored. This study aimed to identify the incidence of acute kidney injury (AKI) in patients with COVID-19 and to evaluate its impact on patient outcomes. This retrospective study included 704 patients with COVID-19 who were hospitalized at two hospitals in Daegu, Korea from February 19 to March 31, 2020. AKI was defined according to the serum creatinine criteria in the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. The final date of follow-up was May 1, 2020. Of the 704 patients, 28 (4.0%) developed AKI. Of the 28 patients with AKI, 15 (53.6%) were found to have AKI stage 1, 3 (10.7%) had AKI stage 2, and 10 (35.7%) had AKI stage 3. Among these patients, 12 (42.9%) recovered from AKI. In the patients with AKI, the rates of admission to intensive care unit (ICU), administration of mechanical ventilator (MV), and in-hospital mortality were significantly higher than in patients without AKI. Multivariable analysis revealed that old age (Hazard ratio [HR] = 4.668, 95% confidence interval [CI] = 1.250-17.430, p = 0.022), high neutrophil-to-lymphocyte ratio (HR = 1.167, 95% CI = 1.078-1.264, p < 0.001), elevated creatinine kinase (HR = 1.002, 95% CI = 1.001-1.004, p = 0.007), and severe AKI (HR = 12.199, 95% CI = 4.235-35.141, p < 0.001) were independent risk factors for in-hospital mortality. The Kaplan-Meier curves showed that the cumulative survival rate was lowest in the AKI stage 3 group (p < 0.001). In conclusion, the incidence of AKI in patients with COVID-19 was 4.0%. Severe AKI was associated with in-hospital death. |*Acute Kidney Injury/blood/etiology/mortality/therapy[MESH] |*COVID-19/blood/complications/mortality/therapy[MESH] |*Critical Care[MESH] |*Hospital Mortality[MESH] |*Patient Admission[MESH] |*SARS-CoV-2[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Disease-Free Survival[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Republic of Korea/epidemiology[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH] |Severity of Illness Index[MESH]Severe acute kidney injury in COVID-19 patients is associated with in-(epmc).pdf DeepDyve Pubget Overpricing