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10.1016/j.medj.2020.11.005 http://scihub22266oqcxt.onion/10.1016/j.medj.2020.11.005 33294881!7713589!33294881     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med 2020 ; 1 (1): 90-102 Nephropedia Template TP {{tp|p=33294881|t=2020. The Potential for Repurposing Anti-TNF as a Therapy for the Treatment of COVID-19 |pdf=|usr=}}{{33294881}} gab.com Text The Potential for Repurposing Anti-TNF as a Therapy for the Treatment of COVID-19 JO: Med http://www.kidney.de/pget.php?&tw=1&pmid=33294881 #FOAvip Coronavirus disease 2019 (COVID-19) currently has few effective treatments. Given the uncertainty surrounding the effectiveness and uptake of a vaccine, it is important that the search for treatments continue. An exaggerated inflammatory state is likely responsible for much of the morbidity and mortality in COVID-19. Elevated levels of tumor necrosis factor (TNF), a key pro-inflammatory cytokine, have been shown to be associated with increased COVID-19 mortality. In patients with rheumatoid arthritis, TNF blockade reduces not only biologically active TNF but other pro-inflammatory cytokines important in COVID-19 hyperinflammation. Observational data from patients already on anti-TNF therapy show a reduced rate of COVID-19 poor outcomes and death compared with other immune-suppressing therapies. Anti-TNF has a long history of safe use, including in special at-risk populations, and is widely available. The case to adequately assess anti-TNF as a treatment for COVID-19 is compelling. Twit Text FOAVip The Potential for Repurposing Anti-TNF as a Therapy for the Treatment of COVID-19 ????Med http://www.kidney.de/pget.php?&tw=1&pmid=33294881 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33294881 #FOAvip English Wikipedia <ref>{{Cite pmid|33294881}}</ref> The Potential for Repurposing Anti-TNF as a Therapy for the Treatment of COVID-19 #MMPMID33294881 Robinson PC; Liew DFL; Liew JW; Monaco C; Richards D; Shivakumar S; Tanner HL; Feldmann M Med 2020[Dec]; 1 (1): 90-102 PMID33294881show ga Coronavirus disease 2019 (COVID-19) currently has few effective treatments. Given the uncertainty surrounding the effectiveness and uptake of a vaccine, it is important that the search for treatments continue. An exaggerated inflammatory state is likely responsible for much of the morbidity and mortality in COVID-19. Elevated levels of tumor necrosis factor (TNF), a key pro-inflammatory cytokine, have been shown to be associated with increased COVID-19 mortality. In patients with rheumatoid arthritis, TNF blockade reduces not only biologically active TNF but other pro-inflammatory cytokines important in COVID-19 hyperinflammation. Observational data from patients already on anti-TNF therapy show a reduced rate of COVID-19 poor outcomes and death compared with other immune-suppressing therapies. Anti-TNF has a long history of safe use, including in special at-risk populations, and is widely available. The case to adequately assess anti-TNF as a treatment for COVID-19 is compelling. |*COVID-19 Drug Treatment[MESH] |Cytokines[MESH] |Humans[MESH] |SARS-CoV-2[MESH] |Tumor Necrosis Factor Inhibitors/therapeutic use[MESH]The Potential for Repurposing Anti-TNF as a Therapy for the Treatment (epmc).pdf DeepDyve Pubget Overpricing