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10.1016/j.bioactmat.2020.11.016 http://scihub22266oqcxt.onion/10.1016/j.bioactmat.2020.11.016 33294730!7689277!33294730     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioact+Mater 2021 ; 6 (6): 1513-1527 Nephropedia Template TP {{tp|p=33294730|t=2021. Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine |pdf=|usr=}}{{33294730}} gab.com Text Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine JO: Bioact Mater http://www.kidney.de/pget.php?&tw=1&pmid=33294730 #FOAvip Combining chemo-therapeutics with immune checkpoint inhibitors facilitates killing cancer cells and activating the immune system through inhibiting immune escape. However, their treatment effects remain limited due to the compromised accumulation of both drugs and inhibitors in certain tumor tissues. Herein, a new poly (acrylamide-co-acrylonitrile-co-vinylimidazole-co-bis(2-methacryloyl) oxyethyl disulfide) (PAAVB) polymer-based intelligent platform with controllable upper critical solution temperature (UCST) was used for the simultaneous delivery of paclitaxel (PTX) and curcumin (CUR). Additionally, a hyaluronic acid (HA) layer was coated on the surface of PAAVB NPs to target the CD44-overexpressed tumor cells. The proposed nanomedicine demonstrated a gratifying accumulation in tumor tissue and uptake by cancer cells. Then, the acidic microenvironment and high level of glutathione (GSH) in cancer cells could spontaneously decrease the UCST of polymer, leading to the disassembly of the NPs and rapid drug release at body temperature without extra-stimuli. Significantly, the released PTX and CUR could induce the immunogenic cell death (ICD) to promote adaptive anti-tumor immunogenicity and inhibit immunosuppression through suppressing the activity of indoleamine 2,3-dioxygenase 1 (IDO1) enzyme respectively. Therefore, the synergism of this intelligent nanomedicine can suppress primary breast tumor growth and inhibit their lung metastasis. Twit Text FOAVip Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine ????Bioact Mater http://www.kidney.de/pget.php?&tw=1&pmid=33294730 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33294730 #FOAvip English Wikipedia <ref>{{Cite pmid|33294730}}</ref> Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine #MMPMID33294730 Wang Y; Gao D; Liu Y; Guo X; Chen S; Zeng L; Ma J; Zhang X; Tian Z; Yang Z Bioact Mater 2021[Jun]; 6 (6): 1513-1527 PMID33294730show ga Combining chemo-therapeutics with immune checkpoint inhibitors facilitates killing cancer cells and activating the immune system through inhibiting immune escape. However, their treatment effects remain limited due to the compromised accumulation of both drugs and inhibitors in certain tumor tissues. Herein, a new poly (acrylamide-co-acrylonitrile-co-vinylimidazole-co-bis(2-methacryloyl) oxyethyl disulfide) (PAAVB) polymer-based intelligent platform with controllable upper critical solution temperature (UCST) was used for the simultaneous delivery of paclitaxel (PTX) and curcumin (CUR). Additionally, a hyaluronic acid (HA) layer was coated on the surface of PAAVB NPs to target the CD44-overexpressed tumor cells. The proposed nanomedicine demonstrated a gratifying accumulation in tumor tissue and uptake by cancer cells. Then, the acidic microenvironment and high level of glutathione (GSH) in cancer cells could spontaneously decrease the UCST of polymer, leading to the disassembly of the NPs and rapid drug release at body temperature without extra-stimuli. Significantly, the released PTX and CUR could induce the immunogenic cell death (ICD) to promote adaptive anti-tumor immunogenicity and inhibit immunosuppression through suppressing the activity of indoleamine 2,3-dioxygenase 1 (IDO1) enzyme respectively. Therefore, the synergism of this intelligent nanomedicine can suppress primary breast tumor growth and inhibit their lung metastasis. äImmunogenic-cell-killing and immunosuppression-inhibiting nanomedicine(epmc).pdf DeepDyve Pubget Overpricing