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10.1155/2020/8715756

http://scihub22266oqcxt.onion/10.1155/2020/8715756
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33294084!7714605!33294084
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suck abstract from ncbi


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pmid33294084      Can+Respir+J 2020 ; 2020 (ä): 8715756
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  • Detection of Viruses by Multiplex Real-Time Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of Patients with Nonresponding Community-Acquired Pneumonia #MMPMID33294084
  • Zhang H; Han Y; Jin Z; Ying Y; Lan F; Huang H; Wang S; Zhou H; Zhang R; Hua W; Shen H; Li W; Yan F
  • Can Respir J 2020[]; 2020 (ä): 8715756 PMID33294084show ga
  • BACKGROUND: Nonresponding pneumonia is responsible for the most mortality of community-acquired pneumonia (CAP). However, thus far, it is not clear whether viral infection plays an important role in the etiology of nonresponding CAP and whether there is a significant difference in the clinical characteristics between viral and nonviral nonresponding CAP. METHODS: From 2016 to 2019, nonresponding CAP patients were retrospectively enrolled in our study. All patients received bronchoalveolar lavage (BAL) and virus detection in BAL fluid by multiplex real-time polymerase chain reaction (PCR), and clinical, laboratory, and radiographic data were collected. RESULTS: A total of 43 patients were included. The median age was 62 years, and 65.1% of patients were male. Overall, 20 patients (46.5%) were identified with viral infection. Of these viruses, influenza virus (n = 8) and adenovirus (n = 7) were more frequently detected, and others included herpes simplex virus, human enterovirus, cytomegalovirus, human coronavirus 229E, rhinovirus, and parainfluenza virus. Compared with nonviral nonresponding CAP, only ground-glass opacity combined with consolidation was a more common imaging manifestation in viral nonresponding CAP. However, no obvious differences were found in clinical and laboratory findings between the presence and the absence of viral infections. CONCLUSIONS: Viral infections were particularly frequent in adults with nonresponding CAP. The ground-glass opacity combined with consolidation was a specific imaging manifestation for viral nonresponding CAP, while the clinical and laboratory data showed no obvious differences between viral and nonviral nonresponding CAP.
  • |*Multiplex Polymerase Chain Reaction[MESH]
  • |*Real-Time Polymerase Chain Reaction[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Anti-Bacterial Agents/therapeutic use[MESH]
  • |Bronchoalveolar Lavage Fluid/*virology[MESH]
  • |Community-Acquired Infections/diagnosis/virology[MESH]
  • |Diagnosis, Differential[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pneumonia, Bacterial/diagnosis/drug therapy[MESH]
  • |Pneumonia, Viral/*diagnosis/virology[MESH]
  • |Retrospective Studies[MESH]


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