Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Bioelectron+Med 2020 ; 6 (1): 22 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Autonomic balance determines the severity of COVID-19 courses #MMPMID33292846
Leitzke M; Stefanovic D; Meyer JJ; Schimpf S; Schonknecht P
Bioelectron Med 2020[Nov]; 6 (1): 22 PMID33292846show ga
COVID-19 has left mankind desperately seeking how to manage dramatically rising infection rates associated with severe disease progressions. COVID-19 courses range from mild symptoms up to multiple organ failure and death, triggered by excessively high serum cytokine levels (IL 1beta, IL 6, TNF alpha, IL 8). The vagally driven cholinergic anti-inflammatory pathway (CAP) stops the action of nuclear factor kappaB (NF-kappaB), the transcriptional factor of pro-inflammatory cytokines. Thus, well-balanced cytokine release depends on adequate vagal signaling. Coronaviruses replicate using NF-kappaB transcriptional factor as well. By degrading the cytoplasmatic inhibitor of NF-kappaB subunits (IkappaB), coronaviruses induce unrestricted NF-kappaB expression accelerating both, virus replication and cytokine transcription.We hypothesize that CAP detriment due to depressed vagal tone critically determines the severity of COVID-19.