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10.1186/s13601-020-00362-7 http://scihub22266oqcxt.onion/10.1186/s13601-020-00362-7 33292691!7711617!33292691     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Transl+Allergy 2020 ; 10 (1): 58 Nephropedia Template TP {{tp|p=33292691|t=2020. Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies |pdf=|usr=}}{{33292691}} gab.com Text Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies JO: Clin Transl Allergy http://www.kidney.de/pget.php?&tw=1&pmid=33292691 #FOAvip There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARgamma:Peroxisome proliferator-activated receptor, NFkappaB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2alpha:Elongation initiation factor 2alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity. Twit Text FOAVip Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies ????Clin Transl Allergy http://www.kidney.de/pget.php?&tw=1&pmid=33292691 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33292691 #FOAvip English Wikipedia <ref>{{Cite pmid|33292691}}</ref> Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies #MMPMID33292691 Bousquet J; Cristol JP; Czarlewski W; Anto JM; Martineau A; Haahtela T; Fonseca SC; Iaccarino G; Blain H; Fiocchi A; Canonica GW; Fonseca JA; Vidal A; Choi HJ; Kim HJ; Le Moing V; Reynes J; Sheikh A; Akdis CA; Zuberbier T Clin Transl Allergy 2020[Dec]; 10 (1): 58 PMID33292691show ga There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARgamma:Peroxisome proliferator-activated receptor, NFkappaB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2alpha:Elongation initiation factor 2alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity. äNrf2-interacting nutrients and COVID-19: time for research to develop (epmc).pdf DeepDyve Pubget Overpricing