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10.2174/1568026620666201207095117 http://scihub22266oqcxt.onion/10.2174/1568026620666201207095117 33292134!ä!33292134 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33292134.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Top+Med+Chem 2021 ; 21 (6): 442-460 Nephropedia Template TP {{tp|p=33292134|t=2021. An Updated Review on SARS-CoV-2 Main Proteinase (M(Pro)): Protein Structure and Small-Molecule Inhibitors |pdf=|usr=}}{{33292134}} gab.com Text An Updated Review on SARS-CoV-2 Main Proteinase (M(Pro)): Protein Structure and Small-Molecule Inhibitors JO: Curr Top Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=33292134 #FOAvip [Coronaviruses (CoVs) are enveloped positive-stranded RNA viruses with spike (S) protein projections that allow the virus to enter and infect host cells. The S protein is a key virulence factor determining viral pathogenesis, host tropism, and disease pathogenesis. There are currently diverse corona viruses that are known to cause disease in humans. The occurrence of Middle East respiratory syndrome coronavirus (MERS-CoV) and Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), as fatal human CoV diseases, has induced significant interest in the medical field. The novel coronavirus disease (COVID-19) is an infectious disease caused by a novel strain of coronavirus (SAR-CoV-2). The SARS-CoV2 outbreak has been evolved in Wuhan, China, in December 2019, and identified as a pandemic in March 2020, resulting in 53.24 M cases and 1.20M deaths worldwide. SARS-CoV-2 main proteinase (M(Pro)), a key protease of CoV-2, mediates viral replication and transcription. SARS-CoV-2 M(Pro) has been emerged as an attractive target for SARS-CoV-2 drug design and development. Diverse scaffolds have been released targeting SARS-CoV-2 M(Pro). In this review, we culminate the latest published information about SARS-CoV-2 main proteinase (M(Pro)) and reported inhibitors. Twit Text FOAVip An Updated Review on SARS-CoV-2 Main Proteinase (M(Pro)): Protein Structure and Small-Molecule Inhibitors ????Curr Top Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=33292134 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33292134 #FOAvip English Wikipedia <ref>{{Cite pmid|33292134}}</ref> An Updated Review on SARS-CoV-2 Main Proteinase (M(Pro)): Protein Structure and Small-Molecule Inhibitors #MMPMID33292134 Sabbah DA; Hajjo R; Bardaweel SK; Zhong HA Curr Top Med Chem 2021[]; 21 (6): 442-460 PMID33292134show ga [Coronaviruses (CoVs) are enveloped positive-stranded RNA viruses with spike (S) protein projections that allow the virus to enter and infect host cells. The S protein is a key virulence factor determining viral pathogenesis, host tropism, and disease pathogenesis. There are currently diverse corona viruses that are known to cause disease in humans. The occurrence of Middle East respiratory syndrome coronavirus (MERS-CoV) and Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), as fatal human CoV diseases, has induced significant interest in the medical field. The novel coronavirus disease (COVID-19) is an infectious disease caused by a novel strain of coronavirus (SAR-CoV-2). The SARS-CoV2 outbreak has been evolved in Wuhan, China, in December 2019, and identified as a pandemic in March 2020, resulting in 53.24 M cases and 1.20M deaths worldwide. SARS-CoV-2 main proteinase (M(Pro)), a key protease of CoV-2, mediates viral replication and transcription. SARS-CoV-2 M(Pro) has been emerged as an attractive target for SARS-CoV-2 drug design and development. Diverse scaffolds have been released targeting SARS-CoV-2 M(Pro). In this review, we culminate the latest published information about SARS-CoV-2 main proteinase (M(Pro)) and reported inhibitors. |Amino Acid Sequence[MESH] |Antiviral Agents/*chemistry/classification/pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |Catalytic Domain[MESH] |Coronavirus 3C Proteases/*antagonists & inhibitors/chemistry/genetics/metabolism[MESH] |Drug Discovery[MESH] |Gene Expression[MESH] |High-Throughput Screening Assays[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH] |Phytochemicals/*chemistry/classification/pharmacology[MESH] |Protease Inhibitors/*chemistry/classification/pharmacology[MESH] |Protein Binding[MESH] |Protein Interaction Domains and Motifs[MESH] |Protein Structure, Secondary[MESH] |SARS-CoV-2/*chemistry/drug effects/enzymology[MESH]An Updated Review on SARS-CoV-2 Main Proteinase (M(Pro)): Protein Stru(epmc).pdf DeepDyve Pubget Overpricing