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10.3390/ijms21239289 http://scihub22266oqcxt.onion/10.3390/ijms21239289 33291453!7730764!33291453     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33291453&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (23): ä Nephropedia Template TP {{tp|p=33291453|t=2020. Advances in Transgenic Mouse Models to Study Infections by Human Pathogenic Viruses |pdf=|usr=}}{{33291453}} gab.com Text Advances in Transgenic Mouse Models to Study Infections by Human Pathogenic Viruses JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33291453 #FOAvip Medical research is changing into direction of precision therapy, thus, sophisticated preclinical models are urgently needed. In human pathogenic virus research, the major technical hurdle is not only to translate discoveries from animals to treatments of humans, but also to overcome the problem of interspecies differences with regard to productive infections and comparable disease development. Transgenic mice provide a basis for research of disease pathogenesis after infection with human-specific viruses. Today, humanized mice can be found at the very heart of this forefront of medical research allowing for recapitulation of disease pathogenesis and drug mechanisms in humans. This review discusses progress in the development and use of transgenic mice for the study of virus-induced human diseases towards identification of new drug innovations to treat and control human pathogenic infectious diseases. Twit Text FOAVip Advances in Transgenic Mouse Models to Study Infections by Human Pathogenic Viruses ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33291453 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33291453 #FOAvip English Wikipedia <ref>{{Cite pmid|33291453}}</ref> Advances in Transgenic Mouse Models to Study Infections by Human Pathogenic Viruses #MMPMID33291453 Masemann D; Ludwig S; Boergeling Y Int J Mol Sci 2020[Dec]; 21 (23): ä PMID33291453show ga Medical research is changing into direction of precision therapy, thus, sophisticated preclinical models are urgently needed. In human pathogenic virus research, the major technical hurdle is not only to translate discoveries from animals to treatments of humans, but also to overcome the problem of interspecies differences with regard to productive infections and comparable disease development. Transgenic mice provide a basis for research of disease pathogenesis after infection with human-specific viruses. Today, humanized mice can be found at the very heart of this forefront of medical research allowing for recapitulation of disease pathogenesis and drug mechanisms in humans. This review discusses progress in the development and use of transgenic mice for the study of virus-induced human diseases towards identification of new drug innovations to treat and control human pathogenic infectious diseases. |*Disease Models, Animal[MESH] |*Mice, Transgenic[MESH] |Animals[MESH] |Gene Expression Regulation, Viral[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Immune System[MESH] |Organ Specificity[MESH] |Receptors, Cell Surface/metabolism[MESH] |Viral Tropism[MESH] |Virus Diseases/diagnosis/*etiology/therapy[MESH]Advances in Transgenic Mouse Models to Study Infections by Human Patho(epmc).pdf DeepDyve Pubget Overpricing