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10.1016/j.jviromet.2020.114032 http://scihub22266oqcxt.onion/10.1016/j.jviromet.2020.114032 33290786!7718587!33290786     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Virol+Methods 2021 ; 289 (ä): 114032 Nephropedia Template TP {{tp|p=33290786|t=2021. Genomic and evolutionary comparison between SARS-CoV-2 and other human coronaviruses |pdf=|usr=}}{{33290786}} gab.com Text Genomic and evolutionary comparison between SARS-CoV-2 and other human coronaviruses JO: J Virol Methods http://www.kidney.de/pget.php?&tw=1&pmid=33290786 #FOAvip Three highly pathogenic human coronaviruses can cause severe acute respiratory syndrome (SARS-CoV, SARS-CoV-2 and MERS-CoV). Although phylogenetic analyses have indicated ancient origin of human coronaviruses from animal relatives, their evolutionary history remains to be established. Using phylogenetics and "high order genomic structures" including trimer spectrums, codon usage and dinucleotide suppression, we observed distinct clustering of all human coronaviruses that formed phylogenetic clades with their closest animal relatives, indicating they have encompassed long evolutionary histories within specific ecological niches before jumping species barrier to infect humans. The close relationships between SARS-CoV and SARS-CoV-2 imply similar evolutionary origin. However, a lower Effective Codon Number (ENC) pattern and CpG dinucleotide suppression in SARS-CoV-2 genomes compared to SARS-CoV and MERS-CoV may imply a better host fitness, and thus their success in sustaining a pandemic. Characterization of coronavirus heterogeneity via complementary approaches enriches our understanding on the evolution and virus-host interaction of these emerging human pathogens while the underlying mechanistic basis in pathogenicity warrants further investigation. Twit Text FOAVip Genomic and evolutionary comparison between SARS-CoV-2 and other human coronaviruses ????J Virol Methods http://www.kidney.de/pget.php?&tw=1&pmid=33290786 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33290786 #FOAvip English Wikipedia <ref>{{Cite pmid|33290786}}</ref> Genomic and evolutionary comparison between SARS-CoV-2 and other human coronaviruses #MMPMID33290786 Chen Z; Boon SS; Wang MH; Chan RWY; Chan PKS J Virol Methods 2021[Mar]; 289 (ä): 114032 PMID33290786show ga Three highly pathogenic human coronaviruses can cause severe acute respiratory syndrome (SARS-CoV, SARS-CoV-2 and MERS-CoV). Although phylogenetic analyses have indicated ancient origin of human coronaviruses from animal relatives, their evolutionary history remains to be established. Using phylogenetics and "high order genomic structures" including trimer spectrums, codon usage and dinucleotide suppression, we observed distinct clustering of all human coronaviruses that formed phylogenetic clades with their closest animal relatives, indicating they have encompassed long evolutionary histories within specific ecological niches before jumping species barrier to infect humans. The close relationships between SARS-CoV and SARS-CoV-2 imply similar evolutionary origin. However, a lower Effective Codon Number (ENC) pattern and CpG dinucleotide suppression in SARS-CoV-2 genomes compared to SARS-CoV and MERS-CoV may imply a better host fitness, and thus their success in sustaining a pandemic. Characterization of coronavirus heterogeneity via complementary approaches enriches our understanding on the evolution and virus-host interaction of these emerging human pathogens while the underlying mechanistic basis in pathogenicity warrants further investigation. |*Evolution, Molecular[MESH] |*Genome, Viral[MESH] |Animals[MESH] |Betacoronavirus/*genetics[MESH] |Computational Biology[MESH] |Coronavirus Infections/*virology[MESH] |Databases, Genetic[MESH] |Humans[MESH] |Phylogeny[MESH]Genomic and evolutionary comparison between SARS-CoV-2 and other human(epmc).pdf DeepDyve Pubget Overpricing