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10.1016/j.ijbiomac.2020.12.020 http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2020.12.020 33290767!7836687!33290767     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Biol+Macromol 2021 ; 168 (ä): 474-485 Nephropedia Template TP {{tp|p=33290767|t=2021. Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches |pdf=|usr=}}{{33290767}} gab.com Text Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches JO: Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=33290767 #FOAvip Effective treatment choices to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are limited because of the absence of effective target-based therapeutics. The main object of the current research was to estimate the antiviral activity of cannabinoids (CBDs) against the human coronavirus SARS-CoV-2. In the presented research work, we performed in silico and in vitro experiments to aid the sighting of lead CBDs for treating the viral infections of SARS-CoV-2. Virtual screening was carried out for interactions between 32 CBDs and the SARS-CoV-2 M(pro) enzyme. Afterward, in vitro antiviral activity was carried out of five CBDs molecules against SARS-CoV-2. Interestingly, among them, two CBDs molecules namely Delta(9) -tetrahydrocannabinol (IC(50) = 10.25 muM) and cannabidiol (IC(50) = 7.91 muM) were observed to be more potent antiviral molecules against SARS-CoV-2 compared to the reference drugs lopinavir, chloroquine, and remdesivir (IC(50) ranges of 8.16-13.15 muM). These molecules were found to have stable conformations with the active binding pocket of the SARS-CoV-2 M(pro) by molecular dynamic simulation and density functional theory. Our findings suggest cannabidiol and Delta(9) -tetrahydrocannabinol are possible drugs against human coronavirus that might be used in combination or with other drug molecules to treat COVID-19 patients. Twit Text FOAVip Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches ????Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=33290767 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33290767 #FOAvip English Wikipedia <ref>{{Cite pmid|33290767}}</ref> Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches #MMPMID33290767 Raj V; Park JG; Cho KH; Choi P; Kim T; Ham J; Lee J Int J Biol Macromol 2021[Jan]; 168 (ä): 474-485 PMID33290767show ga Effective treatment choices to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are limited because of the absence of effective target-based therapeutics. The main object of the current research was to estimate the antiviral activity of cannabinoids (CBDs) against the human coronavirus SARS-CoV-2. In the presented research work, we performed in silico and in vitro experiments to aid the sighting of lead CBDs for treating the viral infections of SARS-CoV-2. Virtual screening was carried out for interactions between 32 CBDs and the SARS-CoV-2 M(pro) enzyme. Afterward, in vitro antiviral activity was carried out of five CBDs molecules against SARS-CoV-2. Interestingly, among them, two CBDs molecules namely Delta(9) -tetrahydrocannabinol (IC(50) = 10.25 muM) and cannabidiol (IC(50) = 7.91 muM) were observed to be more potent antiviral molecules against SARS-CoV-2 compared to the reference drugs lopinavir, chloroquine, and remdesivir (IC(50) ranges of 8.16-13.15 muM). These molecules were found to have stable conformations with the active binding pocket of the SARS-CoV-2 M(pro) by molecular dynamic simulation and density functional theory. Our findings suggest cannabidiol and Delta(9) -tetrahydrocannabinol are possible drugs against human coronavirus that might be used in combination or with other drug molecules to treat COVID-19 patients. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/chemistry/pharmacokinetics/*pharmacology[MESH] |COVID-19/*virology[MESH] |Cannabidiol/chemistry/pharmacokinetics/pharmacology[MESH] |Cannabinoids/chemistry/pharmacokinetics/*pharmacology[MESH] |Computer Simulation[MESH] |Coronavirus 3C Proteases/antagonists & inhibitors/chemistry/drug effects[MESH] |Dronabinol/chemistry/pharmacokinetics/pharmacology[MESH] |Drug Evaluation, Preclinical[MESH] |Humans[MESH] |In Vitro Techniques[MESH] |Ligands[MESH] |Models, Biological[MESH] |Molecular Docking Simulation[MESH] |Molecular Dynamics Simulation[MESH] |Pandemics[MESH] |Protease Inhibitors/chemistry/pharmacology[MESH]Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 u(epmc).pdf DeepDyve Pubget Overpricing