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10.1002/jmv.26713

http://scihub22266oqcxt.onion/10.1002/jmv.26713
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33289142!ä!33289142

suck abstract from ncbi


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pmid33289142      J+Med+Virol 2021 ; 93 (4): 2332-2339
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  • Development and validation of a nomogram using on admission routine laboratory parameters to predict in-hospital survival of patients with COVID-19 #MMPMID33289142
  • Chen H; Chen R; Yang H; Wang J; Hou Y; Hu W; Yu J; Li H
  • J Med Virol 2021[Apr]; 93 (4): 2332-2339 PMID33289142show ga
  • To develop and validate a nomogram using on admission data to predict in-hospital survival probabilities of coronavirus disease 2019 (COVID-19) patients. We analyzed 855 COVID-19 patients with 52 variables. The least absolute shrinkage and selection operator regression and multivariate Cox analyses were used to screen significant factors associated with in-hospital mortality. A nomogram was established based on the variables identified by Cox regression. The performance of the model was evaluated by C-index and calibration plots. Decision curve analysis was conducted to determine the clinical utility of the nomogram. Six variables, including neutrophil (hazard ratio [HR], 1.088; 95% confidence interval [CI], [1.0004-1.147]; p < .001), C-reactive protein (HR, 1.007; 95% CI, [1.0026-1.011]; p = .002), IL-6 (HR, 1.001; 95% CI, [1.0003-1.002]; p = .005), d-dimer (HR, 1.034; 95% CI, [1.0111-1.057]; p = .003), prothrombin time (HR 1.086, 95% CI [1.0369-1.139], p < .001), and myoglobin (HR, 1.001; 95% CI, [1.0007-1.002]; p < .001), were identified and applied to develop a nomogram. The nomogram predicted 14-day and 28-day survival probabilities with reasonable accuracy, as assessed by the C-index (0.912) and calibration plots. Decision curve analysis showed relatively wide ranges of threshold probability, suggesting a high clinical value of the nomogram. Neutrophil, C-reactive protein, IL-6, d-dimer, prothrombin time, and myoglobin levels were significantly correlated with in-hospital mortality of COVID-19 patients. Demonstrating satisfactory discrimination and calibration, this model could predict patient outcomes as early as on admission and might serve as a useful triage tool for clinical decision making.
  • |*Nomograms[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/metabolism/*mortality[MESH]
  • |China/epidemiology[MESH]
  • |Female[MESH]
  • |Fibrin Fibrinogen Degradation Products/metabolism[MESH]
  • |Hospital Mortality[MESH]
  • |Hospitalization[MESH]
  • |Hospitals/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Proportional Hazards Models[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Assessment[MESH]
  • |Risk Factors[MESH]


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