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10.1002/jmv.26707 http://scihub22266oqcxt.onion/10.1002/jmv.26707 33289122!7753709!33289122     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (4): 1950-1966 Nephropedia Template TP {{tp|p=33289122|t=2021. Hidden in plain sight: The effects of BCG vaccination in the COVID-19 pandemic |pdf=|usr=}}{{33289122}} gab.com Text Hidden in plain sight: The effects of BCG vaccination in the COVID-19 pandemic JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33289122 #FOAvip To investigate the relationship between Bacille Calmette-Guerin (BCG) vaccination and SARS-CoV-2 by a bioinformatics approach, two datasets for the SARS-CoV-2 infection group and BCG-vaccinated group were downloaded. Differentially Expressed Genes were identified. Gene ontology and pathways were functionally enriched, and networking was constructed in NetworkAnalyst. Lastly, the correlation between post-BCG vaccination and COVID-19 transcriptome signatures was established. A total of 161 DEGs (113 upregulated DEGs and 48 downregulated genes) were identified in the SARS-CoV-2 group. In the pathway enrichment analysis, a cross-reference of upregulated Kyoto Encyclopedia of Genes and Genomes pathways in SARS-CoV-2 with downregulated counterparts in the BCG-vaccinated group, resulted in the intersection of 45 common pathways, accounting for 86.5% of SARS-CoV-2 upregulated pathways. Of these intersecting pathways, a vast majority were immune and inflammatory pathways with top significance in interleukin-17, tumor necrosis factor, NOD-like receptors, and nuclear factor-kappaB signaling pathways. Given the inverse relationship of the specific differentially expressed gene pathways highlighted in our results, the BCG-vaccine may play a protective role against COVID-19 by mounting a nonspecific immunological response and further investigation of this relationship is warranted. Twit Text FOAVip Hidden in plain sight: The effects of BCG vaccination in the COVID-19 pandemic ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33289122 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33289122 #FOAvip English Wikipedia <ref>{{Cite pmid|33289122}}</ref> Hidden in plain sight: The effects of BCG vaccination in the COVID-19 pandemic #MMPMID33289122 Toraih EA; Sedhom JA; Dokunmu TM; Hussein MH; Ruiz EML; Muthusamy K; Zerfaoui M; Kandil E J Med Virol 2021[Apr]; 93 (4): 1950-1966 PMID33289122show ga To investigate the relationship between Bacille Calmette-Guerin (BCG) vaccination and SARS-CoV-2 by a bioinformatics approach, two datasets for the SARS-CoV-2 infection group and BCG-vaccinated group were downloaded. Differentially Expressed Genes were identified. Gene ontology and pathways were functionally enriched, and networking was constructed in NetworkAnalyst. Lastly, the correlation between post-BCG vaccination and COVID-19 transcriptome signatures was established. A total of 161 DEGs (113 upregulated DEGs and 48 downregulated genes) were identified in the SARS-CoV-2 group. In the pathway enrichment analysis, a cross-reference of upregulated Kyoto Encyclopedia of Genes and Genomes pathways in SARS-CoV-2 with downregulated counterparts in the BCG-vaccinated group, resulted in the intersection of 45 common pathways, accounting for 86.5% of SARS-CoV-2 upregulated pathways. Of these intersecting pathways, a vast majority were immune and inflammatory pathways with top significance in interleukin-17, tumor necrosis factor, NOD-like receptors, and nuclear factor-kappaB signaling pathways. Given the inverse relationship of the specific differentially expressed gene pathways highlighted in our results, the BCG-vaccine may play a protective role against COVID-19 by mounting a nonspecific immunological response and further investigation of this relationship is warranted. |BCG Vaccine/*immunology[MESH] |COVID-19/genetics/*immunology[MESH] |Computational Biology[MESH] |Datasets as Topic[MESH] |Gene Ontology[MESH] |Humans[MESH] |Signal Transduction/immunology[MESH] |Transcriptome[MESH]Hidden in plain sight: The effects of BCG vaccination in the COVID-19 (epmc).pdf DeepDyve Pubget Overpricing