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  • The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2 #MMPMID33288200
  • Jin Z; Wang H; Duan Y; Yang H
  • Biochem Biophys Res Commun 2021[Jan]; 538 (ä): 63-71 PMID33288200show ga
  • The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (M(pro)) and the RNA-dependent RNA polymerase (RdRP), which are responsible for the viral polyprotein proteolytic process and viral genome replication and transcription, respectively, are two attractive drug targets for SARS-CoV-2. This review summarizes up-to-date progress in the structural and pharmacological aspects of those two key targets above. Different classes of inhibitors individually targeting M(pro) and RdRP are discussed, which could promote drug development to treat SARS-CoV-2 infection.
  • |Antiviral Agents/*chemistry/pharmacology[MESH]
  • |Coronavirus 3C Proteases/*antagonists & inhibitors/*chemistry[MESH]
  • |Coronavirus Protease Inhibitors/*chemistry/pharmacology[MESH]
  • |Coronavirus RNA-Dependent RNA Polymerase/*antagonists & inhibitors/*chemistry[MESH]
  • |Drug Design[MESH]
  • |Enzyme Inhibitors/*chemistry/pharmacology[MESH]
  • |Humans[MESH]
  • |Protein Conformation[MESH]
  • |SARS-CoV-2/drug effects/*enzymology[MESH]

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  • suck abstract from ncbi

    63 ä.538 2021